SUMMARY β-Lactam antibiotics have been widely used as therapeutic agents for the past
70 years, resulting in emergence of an abundance of β-lactam-inactivating β-lactamases …

The antibacterial agents currently in clinical development are predominantly derivatives of
well-established antibiotic classes and were selected to address the class-specific …

Carbapenem-resistant Enterobacteriaceae are some of the most important pathogens
responsible for nosocomial infections, which can be challenging to treat. The bla NDM …

Since March 2022, there has been an emergence of multidrug-resistant organisms (MDRO)
in the Netherlands in patients originating from Ukraine (58 patients, 75 isolates). For about …

The aim of this study was to examine antibiotic resistance profiles and diversity of β-
lactamases in Escherichia coli present within the population and the potential spread of …

Background The molecular characteristics of carbapenem-resistant Escherichia coli
(CREco) remain unclear. Methods We conducted a multi-center bacterial resistance …

Abstract Background and Aim The global rise of antimicrobial resistance among bacterial
strains is a rapidly growing challenge and is becoming a major public health concern. This …

Carbapenem-resistant Escherichia coli (CREC) has become a major public health problem
worldwide. To date, there is a limited understanding of the global distribution of CREC. In …

Carbapenems are considered last-line beta-lactams for the treatment of infections caused by
multidrug-resistant Gram-negative bacteria. However, their activity is compromised by the …

In the past decade, the prevalence of multidrug-resistant gram-negative (MDR-GN) bacterial
infections has increased significantly, leading to higher rates of morbidity and mortality …