Importance Although considered a rare disease with fewer than 200 000 cases annually in
the US, sickle cell disease (SCD) is the most common and clinically significant inherited …

The genome between socially constructed racial groups is 99.5%–99.9% identical; the 0.1%–
0.5% variation between any two unrelated individuals is greatest between individuals in the …

Approximately 100,000 Americans have sickle cell disease (SCD). In the USA, the majority
of patients with SCD are of African descent. Due to persistent racial and ethnic disparities in …

Sickle cell disease (SCD) is the most common inherited blood disorder in the United States.
It is a medically and socially complex, multisystem illness that affects individuals throughout …

Objectives Sickle cell disease (SCD) leads to chronic and acute complications that require
specialised care to manage symptoms and optimise clinical results. The National Heart …

Importance Despite hydroxyurea being an established treatment for sickle cell disease
(SCD), it remains underused. The recent approval of the disease-modifying treatments …

ABSTRACT Purpose and Objectives: The purpose of this discussion is to review the barriers
to care for patients with sickle cell disease (SCD). Chronic pain and the perception of …

Background: Sickle-cell disease (SCD) causes significant morbidity, premature mortality,
and high disease burden, resulting in frequent health care use. Comanagement may …

Background Sickle cell disease (SCD) is associated with a wide range of complications.
However, a multitude of barriers prevent SCD patients from receiving adequate healthcare …

METHODS We analyzed publicly available data from the Centers for Disease Control and
Prevention WONDER database, a compilation of national-level mortality statistics from 1979 …