Towards metabolic biomarkers of insulin resistance and type 2 diabetes: progress from the metabolome

LD Roberts, A Koulman, JL Griffin - The lancet Diabetes & …, 2014 - thelancet.com
The complex aetiology of type 2 diabetes makes effective screening, diagnosis and
prognosis a substantial challenge for the physician. The rapidly developing area of …

Eicosanoids in metabolic syndrome

JP Hardwick, K Eckman, YK Lee… - Advances in …, 2013 - Elsevier
Chronic persistent inflammation plays a significant role in disease pathology of cancer,
cardiovascular disease, and metabolic syndrome (MetS). MetS is a constellation of diseases …

[PDF][PDF] Elovl6 promotes nonalcoholic steatohepatitis

T Matsuzaka, A Atsumi, R Matsumori, T Nie… - …, 2012 - Wiley Online Library
Nonalcoholic steatohepatitis (NASH) is associated with obesity and type 2 diabetes, and an
increased risk for liver cirrhosis and cancer. ELOVL family member 6, elongation of very long …

Central role of the PPARγ gene network in coordinating beef cattle intramuscular adipogenesis in response to weaning age and nutrition

SJ Moisá, DW Shike, DB Faulkner… - Gene regulation …, 2014 - journals.sagepub.com
Adipogenic/lipogenic transcriptional networks regulating intramuscular fat deposition (IMF)
in response to weaning age and dietary starch level were studied. The longissimus muscle …

Role of fatty acid elongase Elovl6 in the regulation of energy metabolism and pathophysiological significance in diabetes

T Matsuzaka - Diabetology international, 2021 - Springer
Type 2 diabetes mellitus (T2DM) is an expanding epidemic, closely linked to obesity.
Peripheral insulin resistance and impaired insulin secretion remain the core defects in …

Polymorphism in the ELOVL6 Gene Is Associated with a Major QTL Effect on Fatty Acid Composition in Pigs

J Corominas, Y Ramayo-Caldas, A Puig-Oliveras… - PloS one, 2013 - journals.plos.org
Background The ELOVL fatty acid elongase 6 (ELOVL6), the only elongase related to de
novo lipogenesis, catalyzes the rate-limiting step in the elongation cycle by controlling the …

Fatty acid metabolism: Implications for diet, genetic variation, and disease

J Suburu, Z Gu, H Chen, W Chen, H Zhang, YQ Chen - Food bioscience, 2013 - Elsevier
Cultures across the globe, especially Western societies, are burdened by chronic diseases
such as obesity, metabolic syndrome, cardiovascular disease, and cancer. Several factors …

Low expression of ELOVL6 may be involved in fat loss in white adipose tissue of cancer-associated cachexia

C Jin, S Wang, X Sui, Q Meng, G Wu - Lipids in Health and Disease, 2024 - Springer
Background Cancer-associated cachexia (CAC) arises from malignant tumors and leads to
a debilitating wasting syndrome. In the pathophysiology of CAC, the depletion of fat plays an …

Quantitative Phosphoproteomic Analysis Reveals the Regulatory Networks of Elovl6 on Lipid and Glucose Metabolism in Zebrafish

X Wang, S Sun, X Cao, J Gao - International Journal of Molecular …, 2020 - mdpi.com
Elongation of very long-chain fatty acids protein 6 (Elovl6) has been reported to be
associated with clinical treatments of a variety of metabolic diseases. However, there is no …

Identification of genes mediating branched chain fatty acid elongation

Z Wang, DH Wang, HG Park, Y Yan, Y Goykhman… - Febs …, 2019 - Wiley Online Library
Saturated branched chain fatty acids (BCFA) terminating with either a prop‐2‐yl (iso) or sec‐
butan‐2‐yl (anteiso) group are common bioactive food components consumed from beef …