Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

Innate immunity is the first defense system against invading pathogens. Toll-like receptors
(TLRs) are well-defined pattern recognition receptors responsible for pathogen recognition …

In the past few years, cancer immunotherapy has emerged as a safe and effective
alternative for treatment of cancers that do not respond to classical treatments, including …

Abstract Toll-like receptor 3 (TLR3) is a member of the TLR family, mediating the
transcriptional induction of type I interferons (IFNs), proinflammatory cytokines, and …

There is widespread interest in macrophages as a therapeutic target in cancer. Here, we
demonstrate that trabectedin, a recently approved chemotherapeutic agent, induces rapid …

Research on innate immune signaling and regulation has recently focused on pathogen
recognition receptors (PRRs) and their signaling pathways. Members of PRRs sense …

Toll-like receptors (TLRs) are components of the innate immune system that respond to
exogenous infectious ligands (pathogen-associated molecular patterns, PAMPs) and …

Toll-like receptors (TLRs) are involved in host defence against invading pathogens,
functioning as primary sensors of microbial products and activating signalling pathways that …

Triggering of tumour cell apoptosis is the foundation of many cancer therapies. Death
receptors of the tumour necrosis factor (TNF) superfamily have been largely characterized …

Death receptors (DRs) are members of the tumor necrosis factor receptor superfamily that
possess a cytoplasmic death domain (DD). DRs regulate important operational and …