The methods for the culture and cardiomyocyte differentiation of human embryonic stem
cells, and later human induced pluripotent stem cells (hiPSC), have moved from a complex …

In recent years, there has been a rapid progress in the development of DNA nanomaterials
for biological applications. Owing to their unsurpassed editability, various DNA …

To identify evolutionarily conserved features of replication timing and their relationship to
epigenetic properties, we profiled replication timing genome-wide in four human embryonic …

Human embryonic stem cells (hESCs) have been proposed as a source of dopamine (DA)
neurons for transplantation in Parkinson's disease (PD). We have investigated the effect of in …

How dopamine (DA) neuronal subtypes are specified remains unknown. In this study we
show a robust generation of functional DA neurons from human embryonic stem cells …

Human embryonic stem cells have been defined as self-renewing cells that can give rise to
many types of cells of the body. How and whether these cells can be manipulated to replace …

Spinal cord injury results in the permanent loss of function, causing enormous personal,
social and economic problems. Even though neural regeneration has been proven to be a …

Abstract Background Neural stem cells (NSCs) are powerful research tools for the design
and discovery of new approaches to neurodegenerative disease. Overexpression of the myc …

Pluripotent stem cells have the capacity to self renew and to differentiate to cells of the three
somatic germ layers that comprise an organism. Embryonic stem cells are the most studied …

Parkinson's disease (PD) is one of the most common neurodegenerative disorders, which
affects about 0.3% of the general population. As the population in the developed world ages …