It has been 15 years since the advent of the genome-wide association study (GWAS) era.
Here, we review how this experimental design has realized its promise by facilitating an …

During the past decade, polygenic scores have become a fast-growing area of research in
the behavioural sciences. The ability to directly assess people's genetic propensities has …

Gene–environment correlations affect associations between genetic variants and complex
traits in genome-wide association studies (GWASs). Here we showed in up to 43,516 British …

While volunteer-based studies such as the UK Biobank have become the cornerstone of
genetic epidemiology, the participating individuals are rarely representative of their target …

Psychiatric genetics has made substantial progress in the last decade, providing new
insights into the genetic etiology of psychiatric disorders, and paving the way for precision …

Understanding factors associated with COVID-19 vaccination can highlight issues in public
health systems. Using machine learning, we considered the effects of 2,890 health, socio …

Compelling evidence suggests that human cognitive function is strongly influenced by
genetics. Here, we conduct a large-scale exome study to examine whether rare protein …

Mental health challenges impede the well-being of autistic people. This Review outlines
contributing neurodevelopmental and physical health conditions, rates and developmental …

BackgroundPoor mental health has consistently been associated with substance use
(smoking, alcohol drinking, cannabis use, and consumption of caffeinated drinks). To …

Common genetic variants explain less variation in complex phenotypes than inferred from
family-based studies, and there is a debate on the source of this 'missing heritability'. We …