Objective To assess the effect of tranexamic acid on blood transfusion, thromboembolic
events, and mortality in surgical patients. Design Systematic review and meta-analysis. Data …

The aims of severe perioperative bleeding management are three-fold. First, preoperative
identification by anamesis and laboratory testing of those patients for whom the …

1NHS Blood and Transplant, 2Imperial College Healthcare NHS Trust, London, 3University
College Hospitals NHS Trust, London, 4Serious Hazards of Transfusion, NHS Blood and …

Blood loss and subsequent transfusions are associated with major morbidity and mortality.
The use of antifibrinolytics can reduce blood loss in cardiac surgery, trauma, orthopedic …

Uncontrolled massive bleeding with subsequent derangement of the coagulation system is a
major challenge in the management of both surgical and seriously injured patients. Under …

Craniosynostosis, or premature closure of the skull sutures, is a relatively common disorder
that is treated by expanding and remodeling of the cranium in early infancy to prevent …

BACKGROUND Early administration of tranexamic acid (TXA) has been associated with a
reduction in mortality and blood product requirements in severely injured adults. It has also …

Antifibrinolytic drugs have become almost ubiquitous in their use during major surgery when
bleeding is expected or commonplace. Inhibition of the fibrinolytic pathway after tissue injury …

Total joint arthroplasty and deformity surgery of the spine can require complex reconstructive
procedures accompanied by the potential for major blood loss. In an attempt to minimize the …

Although the safety of the blood supply has been greatly improved, there still remain both
infectious and noninfectious risks to the patient. The incidence of noninfectious transfusion …