Acute heart failure

M Arrigo, M Jessup, W Mullens, N Reza… - Nature Reviews …, 2020 - nature.com
Acute heart failure (AHF) is a syndrome defined as the new onset (de novo heart failure
(HF)) or worsening (acutely decompensated heart failure (ADHF)) of symptoms and signs of …

Chronic intermittent hypoxia in obstructive sleep apnea: a narrative review from pathophysiological pathways to a precision clinical approach

G Labarca, J Gower, L Lamperti, J Dreyse… - Sleep and …, 2020 - Springer
Obstructive sleep apnea syndrome (OSAS) is a prevalent condition caused by dynamic
upper airway collapse during sleep. The pathological impact and consequences are due to …

Endothelin receptor antagonists: status quo and future perspectives for targeted therapy

FC Enevoldsen, J Sahana, M Wehland… - Journal of clinical …, 2020 - mdpi.com
The endothelin axis, recognized for its vasoconstrictive action, plays a central role in the
pathology of pulmonary arterial hypertension (PAH). Treatment with approved endothelin …

ErbB3 governs endothelial dysfunction in hypoxia-induced pulmonary hypertension

JS Bian, J Chen, J Zhang, J Tan, Y Chen, X Yang, Y Li… - Circulation, 2024 - Am Heart Assoc
BACKGROUND: Pulmonary hypertension, characterized by vascular remodeling, currently
lacks curative therapeutic options. The dysfunction of pulmonary artery endothelial cells …

Using Discrete Multi-Physics for studying the dynamics of emboli in flexible venous valves

M Ariane, D Vigolo, A Brill, FGB Nash, M Barigou… - Computers & …, 2018 - Elsevier
Emboli, which are parts of blood clots, can be stuck in the vasculature of various organs
(most frequently, lungs) and cause their malfunction or even death. In this work, using …

Upregulation of endothelial DKK1 (Dickkopf 1) promotes the development of pulmonary hypertension through the Sp1 (specificity protein 1)/SHMT2 (serine …

Q Wang, J Tian, X Li, X Liu, T Zheng, Y Zhao, X Li… - …, 2022 - Am Heart Assoc
Background: Pulmonary hypertension (PH) is a cancer-like proliferative disease, which has
no curative treatment options. The dysfunction of pulmonary artery endothelial cells plays a …

The key roles of negative pressure breathing and exercise in the development of interstitial pulmonary edema in professional male SCUBA divers

O Castagna, J Regnard, E Gempp, P Louge… - Sports medicine …, 2018 - Springer
Background Immersion pulmonary edema is potentially a catastrophic condition; however,
the pathophysiological mechanisms are ill-defined. This study assessed the individual and …

Cardiovascular mechanisms of extravascular lung water accumulation in divers

O Castagna, E Gempp, R Poyet, B Schmid… - The American journal of …, 2017 - Elsevier
This study assessed the relation between altered cardiac function and the development of
interstitial pulmonary edema in scuba divers. Fifteen healthy men performed a 30-minute …

The end of the unique myocardial band: Part II. Clinical and functional considerations

DH MacIver, JB Partridge, P Agger… - European Journal of …, 2018 - academic.oup.com
Two of the leading concepts of mural ventricular architecture are the unique myocardial
band and the myocardial mesh model. We have described, in an accompanying article …

Matricellular protein thrombospondin-1 in pulmonary hypertension: multiple pathways to disease

NM Rogers, K Ghimire, MJ Calzada… - Cardiovascular …, 2017 - academic.oup.com
Matricellular proteins are secreted molecules that have affinities for both extracellular matrix
and cell surface receptors. Through interaction with structural proteins and the cells that …