Epigenetic mechanisms regulate expression of the genome to generate various cell types
during development or orchestrate cellular responses to external stimuli. Recent studies …

One of the key questions in the study of mammalian gene regulation is how epigenetic
methylation patterns on histones and DNA are initiated and established. These stable …

The genomic DNA of all organisms across the three kingdoms of life needs to be compacted
and functionally organized. Key players in these processes are DNA supercoiling …

The link between bacteria and host chromatin remodeling is an emerging topic. The exciting
recent discoveries on bacterial impact on host epigenetics, as discussed in this Review …

Sequence analysis of the genome of the strict intracellular pathogen Chlamydia trachomatis
revealed the presence of a SET domain containing protein, proteins that primarily function …

Vertebrate animals have developed sophisticated host defense mechanisms against
potentially hostile antigens. These mechanisms mainly involve the immune system and the …

Intracellular pathogens that are able to thrive in different environments, such as Legionella
spp. that preferentially live in protozoa in aquatic environments or environmental …

Pathogenic bacteria secrete a variety of proteins that manipulate host cell function by
targeting components of the plasma membrane, cytosol, or organelles. In the last decade …

Chlamydia trachomatis is an obligate intracellular bacterium that causes a diversity of
severe and debilitating diseases worldwide. Sporadic and ongoing outbreaks of …

The molecular support of genetic information, DNA, has to be packaged and organized
inside the tiny volume of nuclei, cells, or virus capsids, in an ordered and dynamical way …