Cadherin EGF LAG seven-pass G-type receptors 1, 2 and 3 (CELSR1-3) form a family of
three atypical cadherins with multiple functions in epithelia and in the nervous system …

Smooth muscle is increasingly recognized as a key mechanical sculptor of epithelia during
embryonic development. Smooth muscle is a mesenchymal tissue that surrounds the …

During branching morphogenesis, a simple cluster of cells proliferates and branches to
generate an arborized network that facilitates fluid flow. The overall architecture of the …

Looping of the initially straight embryonic gut tube is an essential aspect of intestinal
morphogenesis, permitting proper placement of the lengthy small intestine within the …

Tissue folds are structural motifs critical to organ function. In the intestine, bending of a flat
epithelium into a periodic pattern of folds gives rise to villi, finger-like protrusions that enable …

Organs and tissues in multi-cellular organisms exhibit various morphologies. Tubular organs
have multi-scale morphological features which are closely related to their functions. Here we …

Organ and tissue formation are complex three-dimensional processes involving cell division,
growth, migration, and rearrangement, all of which occur within physically constrained …

Although epithelial folding is commonly studied using in vivo animal models, such models
exhibit critical limitations in terms of real-time observation and independent control of …

The molecular mechanisms by which cilia orientation is coordinated within and between
multi-ciliated cells (MCCs) are not fully understood. In the mouse oviduct, MCCs exhibit a …

The gastrointestinal tract is an essential system of organs required for nutrient absorption. As
a simple tube early in development, the primitive gut is patterned along its anterior-posterior …