As small molecule drugs become harder to develop and less cost effective for patient use,
efficient strategies for their property improvement become increasingly important to global …

Spray drying is an efficient technology for solid dispersion manufacturing since it allows
extreme rapid solvent evaporation leading to fast transformation of an API-carrier solution to …

Identification of lead compounds with higher molecular weight and lower aqueous solubility
has become increasingly prevalent with the advent of high throughput screening. Poor …

Introduction: Poor aqueous solubility of active pharmaceutical ingredients (APIs) is one of
the main challenges in the development of new small molecular drugs. Additionally, the …

Poor solubility is a major challenge that can limit the oral bioavailability of many drugs,
including delamanid, a weakly basic nitro-dihydro-imidazooxazole derivative used to treat …

Numerous amorphous solid dispersion (ASD) formulations of celecoxib (CEL) have been
attempted for enhancing the solubility, dissolution rate, and in vivo pharmacokinetics via …

Introduction: The rising demand for pharmaceutical particles with tailored physicochemical
properties has opened new markets for spray drying especially for solubility enhancement …

Multi-ionizable compounds, such as dicarboxylic acids, offer the possibility of forming salts of
drugs with multiple stoichiometries. Attempts to crystallize ciprofloxacin, a poorly water …

Amorphous forms of furosemide sodium salt and furosemide free acid were prepared by
spray drying. For the preparation of the amorphous free acid, methanol was utilised as the …

Salification has a successful track record in modulating the biopharmaceutical properties of
drugs. This is evident from the significant share (40%) of pharmaceutical salts in FDA …