Glial fibrillary acidic protein (GFAP) is the main intermediate filament protein in mature
astrocytes, but also an important component of the cytoskeleton in astrocytes during …

Stroke is an acute insult to the central nervous system (CNS) that triggers a sequence of
responses in the acute, subacute as well as later stages, with prominent involvement of …

Glial fibrillary acidic protein (GFAP) is the main astrocytic intermediate filament (IF). GFAP
splice isoforms show differential expression patterns in the human brain. GFAPδ is …

The proteasome is a large multi-subunit protease responsible for the degradation and
removal of oxidized, misfolded, and polyubiquitinated proteins. The proteasome plays …

Fifty years have passed since the discovery of glial fibrillary acidic protein (GFAP) by
Lawrence Eng and colleagues. Now recognized as a member of the intermediate filament …

In Alzheimer's disease (AD), amyloid plaques are surrounded by reactive astrocytes with an
increased expression of intermediate filaments including glial fibrillary acidic protein (GFAP) …

The proteasome is the major protein degradation system within the cell, comprised of
different proteolytic subunits; amyloid-β is thought to impair its activity in Alzheimer's …

Huntington's disease (HD) is an autosomal dominant inherited neurodegenerative disorder
that is caused by a CAG expansion in the Huntingtin (HTT) gene, leading to HTT inclusion …

The ubiquitin proteasome system (UPS) is crucial for intracellular protein homeostasis and
for degradation of aberrant and damaged proteins. The accumulation of ubiquitinated …

Despite the remarkable complexity of the individual neuron and of neuronal circuits, it has
been clear for quite a while that, in order to understand the functioning of the brain, the …