Abstract The cytokine interleukin-12 (IL-12) was thought to have a central role in T cell–
mediated responses in inflammation for more than a decade after it was first identified …

Following the discovery of T helper 17 (TH17) cells, the past decade has witnessed a major
revision of the TH subset paradigm and substantial progress has been made in deciphering …

Patients with autosomal recessive (AR) IL-12p40 or IL-12Rβ1 deficiency display Mendelian
susceptibility to mycobacterial disease (MSMD) due to impaired IFN-γ production and, less …

Mendelian susceptibility to mycobacterial disease (MSMD) is a rare condition characterized
by predisposition to clinical disease caused by weakly virulent mycobacteria, such as BCG …

The T helper 17 (Th17) cell pathway has been linked by genome-wide association studies to
multiple autoimmune diseases. Identification of the genetic causes of primary …

The body is host to a wide variety of microbial communities from which the immune system
protects us and that are important for the normal development of the immune system and for …

Although the pathogenic mechanisms underlying axial spondyloarthritis (axSpA) and
psoriatic arthritis (PsA) are not fully elucidated, several lines of evidence suggest that …

Autosomal recessive, complete TYK2 deficiency was previously described in a patient (P1)
with intracellular bacterial and viral infections and features of hyper-IgE syndrome (HIES) …

Group 2 innate lymphoid cells (ILC2) include IL-5–and IL-13–producing CRTh2+ CD127+
cells that are implicated in early protective immunity at mucosal surfaces. Whereas …

Inherited IL-12Rβ1 and TYK2 deficiencies impair both IL-12–and IL-23–dependent IFN-γ
immunity and are rare monogenic causes of tuberculosis, each found in less than 1/600,000 …