Low back pain (LBP) is a major reason for disability, and symptomatic intervertebral disc
(IVD) degeneration (IDD) contributes to roughly 40% of all LBP cases. Current treatment …

Herba Epimedii is a famous herb collected from China and Korea. It has been used for
impotency, osteoporosis, and amnestic treatment for thousands of years. Icariin, a typical …

The cost-effectiveness of presently used therapies is a problem in overall redox-based
management, which is posing a significant financial burden on communities across the …

Osteoarthritis (OA) is a common chronic and degenerative joint condition that is mainly
characterized by cartilage degradation, osteophyte formation, and joint stiffness. The NF-κB …

Context Cyanidin has been shown to have therapeutic potential in osteoarthritis. However, it
is unclear whether cyanidin prevents the progression of intervertebral disc degeneration …

Cisplatin, as an effective chemotherapeutic agent, is widely used to treat verious types of
cancers. Nephrotoxicity induced by cisplatin seriously limits its clinical application. Icariin, a …

Activated astrocytes secrete inflammatory cytokines such as interleukin-1β (IL-1β) into the
extracellular milieu, damaging surrounding neurons and involving in the pathogenesis of …

Icariin is a primary active component of the traditional Chinese medicinal plant Epimedium
grandiflorum. A range of pharmacological effects of icariin has been researched by modern …

Puerarin (PUR), an 8‐C‐glucoside of daidzein extracted from Pueraria plants, is closely
related to autophagy, reduced reactive oxygen species (ROS) production, and anti …

Postmenopausal osteoporosis (PMOP) is a systemic chronic bone metabolic disease
caused by the imbalance between bone formation and bone resorption mediated by …