A G-quadruplex (G4) is a well-known nucleic acid secondary structure comprising guanine-
rich sequences, and has profound implications for various pharmacological and biological …

AG‐quadruplex is a nucleic acid secondary structure that is adopted by guanine‐rich
sequences, and is considered to be relevant in various pharmacological and biological …

There are over 700,000 putative G4-quadruplexes (G4Qs) in the human genome, found
largely in promoter regions, telomeres, and other regions of high regulation. Growing …

G-quadruplex is a three-dimensional secondary structure of nucleic acids formed by the
Hoogsteen hydrogen pairing of four guanines. Diverse topologies of G-quadruplex could be …

G-quadruplex (G4) and i-motif (iM) are four-stranded non-canonical nucleic acid structural
arrangements. Recent evidences suggest that these DNA structures exist in living cells and …

The promoter regions of important oncogenes such as BCL2 and KRAS contain GC-rich
sequences that can form distinctive noncanonical DNA structures involved in the regulation …

G-quadruplexes (G4) are now extensively recognised as a peculiar non-canonical DNA
geometry that plays a prime importance role in processes of biological relevance whose …

As the powerhouses of the eukaryotic cell, mitochondria must maintain their genomes which
encode proteins essential for energy production. Mitochondria are characterized by guanine …

Over the past two decades biologists and bioinformaticians have unearthed substantial
evidence supporting a role for G-quadruplexes as important mediators of biological …

In the search for new drug-like selective G-quadruplex binders, a bioinspired design focused
on the use of nucleobases as synthons in a multicomponent reaction was herein proved to …