Behaviours such as eating, copulating, defending oneself or taking addictive drugs begin
with a motivation to initiate the behaviour. Both this motivational drive and the behaviours …

Deciding what to do and when to move is vital to our survival. Clinical and fundamental
studies have identified basal ganglia circuits as critical for this process. The main input …

The striatum integrates excitatory inputs from the cortex and the thalamus to control diverse
functions. Although the striatum is thought to consist of sensorimotor, associative and limbic …

The cortex projects to the dorsal striatum topographically, to regulate behaviour,–, but
spiking activity in the two structures has previously been reported to have markedly different …

The pedunculopontine nucleus (PPN) has long been considered an interface between the
basal ganglia and motor systems, and its ability to regulate arousal states puts the PPN in a …

In Parkinson's disease, the progressive neurodegeneration of nigrostriatal dopaminergic
neurons in the substantia nigra pars compacta (SNc) is associated with classic motor …

Predictive processing is a computational framework that aims to explain how the brain
processes sensory information by making predictions about the environment and minimizing …

The thalamic parafascicular nucleus (PF), an excitatory input to the basal ganglia, is targeted
with deep-brain stimulation to alleviate a range of neuropsychiatric symptoms. Furthermore …

Because of our limited knowledge of the functional role of the thalamostriatal system, this
massive network is often ignored in models of the pathophysiology of brain disorders of …

The purpose of this review is to bridge the gap between earlier literature on striatal
cholinergic interneurons and mechanisms of microcircuit interaction demonstrated with the …