Age‐related macular degeneration (AMD) is a major cause of vision impairment in the
Western World, and with the aging world population, its incidence is increasing. As of today …

Geographic atrophy (GA) secondary to age-related macular degeneration (AMD) is a retinal
neurodegenerative disorder. Human genetic data support the complement system as a key …

Age-related macular degeneration (AMD) is a leading cause of severe vision loss
worldwide, with a global prevalence that is predicted to substantially increase. Identifying …

Preservation of photoreceptors beyond areas of retinal pigment epithelium atrophy is a
critical treatment goal in eyes with geographic atrophy (GA) to prevent vision loss. Thus, we …

Dysregulation of the alternative pathway (AP) of the complement system is a significant
contributor to age-related macular degeneration (AMD), a primary cause of irreversible …

Despite comprehensive research efforts over the last decades, the pathomechanisms of age-
related macular degeneration (AMD) remain far from being understood. Large-scale …

Age-related macular degeneration (AMD) is a progressive neurodegenerative disease
affecting the central area (macula lutea) of the retina. Research on the pathogenic …

PURPOSE To discuss the clinical trial results leading to the US Food and Drug
Administration (FDA) approval of anti-complement therapies for geographic atrophy (GA) …

Genetic factors contribute to the susceptibility of psychotic disorders, but less is known how
they affect psychotic disease-course development. Utilizing polygenic scores (PGSs) in …

Purpose: The purpose of this study was to examine retinal topographical differences
between intermediate age-related macular degeneration (iAMD) with reticular …