Every cell in nature carries a rich surface coat of glycans, its glycocalyx, which constitutes
the cell's interface with its environment. In eukaryotes, the glycocalyx is composed of …

Neuronal growth cones navigate over long distances along specific pathways to find their
correct targets. The mechanisms and molecules that direct this pathfinding are the topics of …

The functioning of the nervous system depends upon the underlying detailed and highly
stereotyped patterns of neuronal connectivity. How these precise patterns of synaptic …

We used the enhancer detection/GAL4 system in Drosophila to direct increased levels of
Fasciclin II (Fas II) expression on motoneuron growth cones and axons and to direct ectopic …

Polysialic acid (PSA) is a cell-surface glycan with an enormous hydrated volume that serves
to modulate the distance between cells. This regulation has direct effects on several cellular …

To elucidate molecular mechanisms underlying activity-dependent synaptic remodeling in
the developing mammalian visual system, we screened for genes whose expression in the …

The rapid growth of infant brains places an exceptionally high demand on the supply of
nutrients from the diet, particularly for preterm infants. Sialic acid (Sia) is an essential …

Polysialic acid (PSA) is a linear homopolymer of α2-8-N acetylneuraminic acid whose major
carrier in vertebrates is the neural cell adhesion molecule (NCAM). PSA serves as a potent …

We have found in the adult rat that the persistent expression of a highly polysialylated neural
cell adhesion molecule (NCAM-H) that is generally specific to developing tissues, remains …

Polysialic acid (PSA), a homopolymer attached to the neural cell adhesion molecule
(NCAM), serves as a modulator of cell interactions. Polysialic acid exhibits a highly …