Hairy roots: An untapped potential for production of plant products

KJ Morey, CAM Peebles - Frontiers in Plant Science, 2022 - frontiersin.org
While plants are an abundant source of valuable natural products, it is often challenging to
produce those products for commercial application. Often organic synthesis is too expensive …

Vinca alkaloids as a potential cancer therapeutics: recent update and future challenges

A Banyal, S Tiwari, A Sharma, I Chanana, SKS Patel… - 3 Biotech, 2023 - Springer
Vinca alkaloids including vincristine, vinblastine, vindesine, and vinflunine are
chemotherapeutic compounds commonly used to treat various cancers. Vinca alkaloids are …

Exploring the potential of two Pseudomonas species to produce vincristine from vinblastine via biotransformation

G Srivastava, R Mittal, N Srivastava, D Ganjewala - Scientific Reports, 2024 - nature.com
A biotransformation pair consisting of vinblastine: vincristine present in the Catharanthus
roseus plant is of immense pharmacological significance. In this study, we successfully …

Genome Assembly of the Medicinal Plant Voacanga thouarsii

C Cuello, EA Stander, HJ Jansen… - Genome Biology and …, 2022 - academic.oup.com
Abstract The Apocynaceae tree Voacanga thouarsii, native to southern Africa and
Madagascar, produces monoterpene indole alkaloids (MIA), which are specialized …

[HTML][HTML] Madagascar periwinkle alkaloids: biosynthesis, ethnobotanical attributes, and pharmacological functions

A Sharma, P Tiwari, R Arora… - South African Journal of …, 2022 - Elsevier
The rising incidence of human diseases has necessitated the exploration of alternative
sources of medications, with a refocus and exploration of plant-based metabolites …

Isolation and Identification of Vincristine and Vinblastine Producing Endophytic Fungi from Catharanthus roseus (L.) G. Don

DQ Nguyen, NL Nguyen, VT Nguyen… - Russian Journal of Plant …, 2023 - Springer
Catharanthus roseus (Vinca) is a perennial herbaceous plant that is renowned for its
abundance of vincristine (VCR) and vinblastine (VBL). These vinca alkaloids possess …

[HTML][HTML] Genome-wide identification of Uncaria rhynchophylla bHLH transcription factors and in-vitro validation of UrbHLH1 through interaction with terpenoid indole …

Y Shao, D Mu, L Pan, Z Lu, Y Zhou, H Zhao… - Current Plant …, 2024 - Elsevier
Uncaria rhynchophylla (Gouteng), as an evergreen woody vine belong to Rubiaceae family,
is a traditional medicinal herb in China. Its terpenoid indole alkaloids (TIAs), which have …

Cytotoxic activity of callus extract from Vachellia farnesiana (L) Wight & Arn.

JA Domínguez-Colín, L Buendía-González… - 3 Biotech, 2024 - Springer
The in vitro cultures of Vachellia farnesiana (L) Wight & Arn. have demonstrated cytotoxic
activity through callus extract on the HeLa cell line. Explants excised from in vitro-grown …

Gene coexpression networks allow the discovery of two strictosidine synthases underlying monoterpene indole alkaloid biosynthesis in Uncaria rhynchophylla

C Jiang, J Yu, X Fei, X Pan, N Zhu, C Lin… - International Journal of …, 2023 - Elsevier
Plant-derived monoterpene indole alkaloids (MIAs) from Uncaria rhynchophylla (UR) have
huge medicinal properties in treating Alzheimer's disease, Parkinson's disease, and …

Seed bacterization with siderophore-producing bacteria: a strategy to enhance growth and alkaloid content in Catharanthus roseus

V Mistry, S Chandwani, N Amaresan, D Kaushik… - World Journal of …, 2025 - Springer
Catharanthus roseus is a medicinal plant widely known for producing monoterpenoid indole
alkaloids (MIAs), including therapeutic compounds such as vinblastine and vincristine …