The essentials of marine biotechnology

A Rotter, M Barbier, F Bertoni, AM Bones… - Frontiers In marine …, 2021 - frontiersin.org
Coastal countries have traditionally relied on the existing marine resources (eg, fishing,
food, transport, recreation, and tourism) as well as tried to support new economic endeavors …

Use of natural products in leishmaniasis chemotherapy: an overview

LFO Gervazoni, GB Barcellos, T Ferreira-Paes… - Frontiers in …, 2020 - frontiersin.org
Leishmaniasis is an infectious parasitic disease that is caused by protozoa of the genus
Leishmania, a member of the Trypanosomatidae family. Leishmaniasis is classified by the …

Potentials of marine natural products against malaria, leishmaniasis, and trypanosomiasis parasites: A review of recent articles

JA Nweze, FN Mbaoji, YM Li, LY Yang… - Infectious diseases of …, 2021 - Springer
Background Malaria and neglected communicable protozoa parasitic diseases, such as
leishmaniasis, and trypanosomiasis, are among the otherwise called diseases for neglected …

Antileishmanial activities of medicinal herbs and phytochemicals in vitro and in vivo: An update for the years 2015 to 2021

AA Hassan, HE Khalid, AH Abdalla, MM Mukhtar… - Molecules, 2022 - mdpi.com
Leishmaniasis is one of the most neglected tropical diseases that present areal public health
problems worldwide. Chemotherapy has several limitations such as toxic side effects, high …

Bioprospecting marine actinomycetes for antileishmanial drugs: current perspectives and future prospects

OF Davies-Bolorunduro, O Osuolale, S Saibu… - Heliyon, 2021 - cell.com
Revived analysis interests in natural products in the hope of discovering new and novel
antileishmanial drug leads have been driven partially by the increasing incidence of drug …

Triose Phosphate Isomerase Structure-Based Virtual Screening and In Vitro Biological Activity of Natural Products as Leishmania mexicana Inhibitors

LD González-Morales, A Moreno-Rodríguez… - Pharmaceutics, 2023 - mdpi.com
Cutaneous leishmaniasis (CL) is a public health problem affecting more than 98 countries
worldwide. No vaccine is available to prevent the disease, and available medical treatments …

Total synthesis of (+)-spiroindimicin A and congeners unveils their antiparasitic activity

Z Zhang, S Ray, L Imlay, LT Callaghan… - Chemical …, 2021 - pubs.rsc.org
The spiroindimicins are a unique class of chlorinated indole alkaloids characterized by three
heteroaromatic rings structured around a congested spirocyclic stereocenter. Here, we …

[HTML][HTML] In vitro activity and mechanism of cell death induction of cyanomethyl vinyl ethers derivatives against Trypanosoma cruzi

CJ Bethencourt-Estrella, S Delgado-Hernández… - International Journal for …, 2023 - Elsevier
Chagas disease causes a problematic pathology that can lead to megacolon and heart
disease, and can even cause the death of the patient. Current therapies for this disease are …

The search for putative hits in combating leishmaniasis: the contributions of natural products over the last decade

PO Sakyi, RK Amewu, RNOA Devine, E Ismaila… - Natural Products and …, 2021 - Springer
Despite advancements in the areas of omics and chemoinformatics, potent novel
biotherapeutic molecules with new modes of actions are needed for leishmaniasis. The …

[HTML][HTML] Multi-target withaferin-A analogues as promising anti-kinetoplastid agents through the programmed cell death

D San Nicolás-Hernández… - Biomedicine & …, 2023 - Elsevier
Leishmaniasis and Chagas disease, two of the most prevalent neglected tropical diseases,
are a world health problem. The harsh reality of these infective diseases is the absence of …