The hippo pathway: A master regulator of liver metabolism, regeneration, and disease

AT Nguyen‐Lefebvre, N Selzner, JL Wrana… - The FASEB …, 2021 - Wiley Online Library
The liver is the only visceral organ in the body with a tremendous capacity to regenerate in
response to insults that induce inflammation, cell death, and injury. Liver regeneration is a …

TEAD4: A key regulator of tumor metastasis and chemoresistance-Mechanisms and therapeutic implications

M Liu, W Hu, X Meng, B Wang - … et Biophysica Acta (BBA)-Reviews on …, 2024 - Elsevier
Cancer metastasis is a complex process influenced by various factors, including epithelial-
mesenchymal transition (EMT), tumor cell proliferation, tumor microenvironment, and cellular …

IGF2BP2 promotes the progression of colorectal cancer through a YAP‐dependent mechanism

J Cui, J Tian, W Wang, T He, X Li, C Gu… - Cancer …, 2021 - Wiley Online Library
To explore the effect of insulin‐like growth factor 2 mRNA‐binding protein 2 (IGF2BP2) on
colorectal cancer (CRC) by recognizing the m6A modification of YAP mRNA thus activating …

Pan-cancer analysis, cell and animal experiments revealing TEAD4 as a tumor promoter in ccRCC

F Li, Y Feng, Q Jiang, J Zhang, F Wu, Q Li, X Jing… - Life Sciences, 2022 - Elsevier
Aims Transcriptional enhanced associate domain (TEAD) transcription factor family, a very
important family in the hippo signaling pathway, has been found to play oncogenic functions …

Verteporfin attenuates trauma‐induced heterotopic ossification of Achilles tendon by inhibiting osteogenesis and angiogenesis involving YAP/β‐catenin signaling

G Luo, Z Sun, H Liu, Z Yuan, W Wang, B Tu… - The FASEB …, 2023 - Wiley Online Library
Heterotopic ossification occurs as a pathological ossification condition characterized by
ectopic bone formation within soft tissues following trauma. Vascularization has long been …

GSTT1 as a Predictive Marker and Enhancer for Osteogenic Potential of Human Adipose‐Derived Stromal/Stem Cells

E Lee, JY Moon, JY Ko, SY Park… - Journal of Bone and …, 2023 - academic.oup.com
Adipose‐derived stromal/stem cells (ASCs) have been extensively studied as cell sources
for regenerative medicine for bone because of their excellent proliferative capacity and the …

Brahma related gene 1 (Brg1) regulates cellular cholesterol synthesis by acting as a co-factor for SREBP2

Z Fan, M Kong, M Li, W Hong, X Fan… - Frontiers in Cell and …, 2020 - frontiersin.org
Hepatocyte is a hub for cholesterol metabolism. Augmented synthesis of cholesterol in the
liver is associated with hypercholesterolemia and contributes to the pathogenesis of a host …

Advances in prognostic and therapeutic targets for hepatocellular carcinoma and intrahepatic cholangiocarcinoma: The hippo signaling pathway

GM Mranda, ZP Xiang, JJ Liu, T Wei, Y Ding - Frontiers in Oncology, 2022 - frontiersin.org
Primary liver cancer is the sixth most frequently diagnosed cancer worldwide and the third
leading cause of cancer-related death. The majority of the primary liver cancer cases are …

[HTML][HTML] Mechano-signaling aspects of hepatocellular carcinoma

M Passi, S Zahler - Journal of Cancer, 2021 - ncbi.nlm.nih.gov
HCC is one of the leading causes of cancer related death worldwide and comprises about
90% of the cases of primary liver cancer. It is generally accompanied by chronic liver fibrosis …

Targeting YAP suppresses ovarian cancer progression through regulation of the PI3K/Akt/mTOR pathway

X Wei, Y Jia, H Lou, J Ma, Q Huang… - Oncology …, 2019 - spandidos-publications.com
Ovarian cancer (OC) is highly metastatic due to frequent peritoneal dissemination, and its
treatment poses a major challenge in clinical practice. Yes‑associated protein (YAP) is …