Osteoblasts, which are bone-forming cells, play pivotal roles in bone modeling and
remodeling. Osteoblast differentiation, also known as osteoblastogenesis, is orchestrated by …

Runx2 is essential for osteoblast development and proper bone formation. A member of the
Runt domain family of transcription factors, Runx2 binds specific DNA sequences to regulate …

Parathyroid hormone (PTH) is an 84-amino-acid polypeptide hormone functioning as a
major mediator of bone remodeling and as an essential regulator of calcium homeostasis …

Parathyroid hormone (PTH) stimulates osteoclast formation by binding to its receptor on
stromal/osteoblastic cells and stimulating the production of receptor activator of NFκB ligand …

Intermittent administration of PTH stimulates bone formation, but the precise mechanisms
responsible for PTH responses in osteoblasts are only incompletely understood. Here we …

Previously we showed that the activator protein-1 site and the runt domain binding site in the
collagenase-3 promoter act cooperatively in response to parathyroid hormone (PTH) in the …

Parathyroid hormone (PTH) binds to its receptor PTH1R (parathyroid hormone 1 receptor) in
osteoblastic cells to regulate bone remodeling and calcium homeostasis. While prolonged …

Osteoporosis can result from the loss of sex hormones and/or aging. Abaloparatide (ABL),
an analog of parathyroid hormone–related protein (PTHrP (1–36)), is the second …

Demyelinating diseases, such as multiple sclerosis, are known to result from acute or
chronic injury to the myelin sheath and inadequate remyelination; however, the underlying …

Parathyroid hormone (PTH) is known to have both catabolic and anabolic effects on bone.
The dual functionality of PTH may stem from its ability to activate two signal transduction …