The development of highly effective and durable vaccines against the human malaria
parasites Plasmodium falciparum and P. vivax remains a key priority. Decades of endeavor …

Immunity to malaria has been linked to the availability and function of helper CD4+ T cells,
cytotoxic CD8+ T cells and γδ T cells that can respond to both the asymptomatic liver stage …

Malaria is a major global health problem that causes significant mortality and morbidity
annually. The therapeutic options are scarce and massively challenged by the emergence of …

The development of vaccines is one of the most significant medical accomplishments which
has helped to eradicate a large number of diseases. It has undergone an evolutionary …

Despite ongoing efforts, a highly effective vaccine against Plasmodium falciparum remains
elusive. Vaccines targeting the pre-erythrocytic stages of the P. falciparum life cycle are the …

Worldwide strategies between 2010 and 2017 aimed at controlling malarial parasites
(mainly Plasmodium falciparum) led to a reduction of just 18% regarding disease incidence …

Interactions between B cells and CD4+ T follicular helper (Tfh) cells are key determinants of
humoral responses. Using samples from clinical trials performed with the malaria vaccine …

Terminal and benign diseases alike in adults, children, pregnant women, and others are
successfully treated by pharmacological inhibitors that target human enzymes. Despite …

Vaccines against parasites have lagged centuries behind those against viral and bacterial
infections, despite the devastating morbidity and widespread effects of parasitic diseases …

Despite continuous efforts, the century-old goal of eradicating malaria still remains. Multiple
control interventions need to be in place simultaneously to achieve this goal. In addition to …