Eye formation is the result of coordinated induction and differentiation processes during
embryogenesis. Disruption of any one of these events has the potential to cause ocular …

Embryonic development of the vertebrate eye begins with the formation of an optic vesicle
which folds inwards to form a double-layered optic cup with a fissure on the ventral surface …

As new genes for A/M are identified in the genomic era, the number of syndromes
associated with A/M has greatly expanded. In this review, we provide a brief synopsis of the …

Ocular coloboma is an uncommon, but often severe, sight-threatening condition that can be
identified from birth. This congenital anomaly is thought to be caused by maldevelopment of …

The gastrulation process relies on complex interactions between developmental signaling
pathways that are not completely understood. Here, we interrogated the contribution of the …

ABSTRACT The Hippo‐Yes associated protein (Yap) pathway plays an important role in
organ size control by regulating cell proliferation, apoptosis, and stem cell renewal. Hippo …

The Hippo pathway is a critical regulator of cell and organ growth and has emerged as a
target for therapeutic intervention in cancers. Its signaling is thought to play an important role …

ARHGAP35 has known roles in cell migration, invasion and division, neuronal
morphogenesis, and gene/mRNA regulation; prior studies indicate a role in cancer in …

Routine diagnostics is biased towards genes and variants with satisfactory evidence, but
rare disorders with only little confirmation of their pathogenicity might be missed. Many of …

The crumbs cell polarity complex plays a crucial role in apical–basal epithelial polarity,
cellular adhesion, and morphogenesis. Homozygous variants in human CRB1 result in …