Cadherin cell-adhesion proteins mediate many facets of tissue morphogenesis. The
dynamic regulation of cadherins in response to various extracellular signals controls cell …

Despite decades of search for anticancer drugs targeting solid tumors, this group of
diseases remains largely incurable, especially if in advanced, metastatic stage. In this …

Regenerative medicine is predicated on understanding the mechanisms regulating
development and applying these conditions to direct stem cell fate. Embryogenesis is …

Integration of receptor tyrosine kinase, integrin, and cadherin activities is crucial for normal
cell growth, motility, and adhesion. Here, we describe roles for p120-catenin (p120) and …

Abstract p120 catenin is the best studied member of a subfamily of proteins that associate
with the cadherin juxtamembrane domain to suppress cadherin endocytosis. p120 also …

Adherens junctions have been traditionally viewed as building blocks of tissue architecture.
The foundations for this view began to change with the discovery that a central component of …

Although originally identified as a Src substrate, p120-catenin (p120) is now known to
regulate cell–cell adhesion through its interaction with the cytoplasmic tail of classical and …

Summary β-catenin-dependent or canonical Wnt signals are fundamental in animal
development and tumor progression. Using Xenopus laevis, we report that the BTB/POZ zinc …

Although p120-catenin regulates adherens junction (AJ) stability in cultured cells, genetic
studies in lower eukaryotes have not revealed a role for this protein in vivo. Using …

Abstract β-catenin is widely regarded as the primary transducer of canonical WNT signals to
the nucleus. In most vertebrates, there are eight additional catenins that are structurally …