G protein-coupled receptors (GPCRs) are plasma membrane proteins associated with an
array of functions. Mutations in these receptors lead to a number of genetic diseases …

Primary ovarian insufficiency (POI) is a heterogeneous disease resulting from non-functional
ovaries in women before the age of 40. It is characterized by primary amenorrhea or …

Background The basal follicle stimulating hormone (FSH)/luteinizing hormone (LH) ratio is a
useful predictor of ovarian response. In this study, we investigated whether the FSH/LH …

Resistant ovary syndrome (ROS) is a rare and difficult gynecological endocrine disorder that
poses a serious risk to women's reproductive health. The clinical features are normal sex …

Misfolding of G protein-coupled receptors (GPCRs) caused by mutations frequently leads to
disease due to intracellular trapping of the conformationally abnormal receptor. Several …

Glycoprotein hormone receptors [thyrotropin (TSHR), luteinizing hormone/chorionic
gonadotropin (LHCGR), and follicle stimulating hormone (FSHR) receptors] are rhodopsin …

Primary ovarian insufficiency (POI) is among the foremost causes of women infertility due to
premature partial or total loss of ovarian function. Resistant ovary syndrome (ROS) is a …

Abstract Premature Ovarian Insufficiency (POI) is a highly heterogeneous condition
characterized by ovarian dysfunction in women occurring before the age of 40, representing …

In recent years, the advent of computational techniques to predict the potential activity of a
drug interacting with a receptor or to predict the structure of unidentified proteins with …

Premature ovarian failure (POF) is defined as the loss of normal ovarian function before the
age of 40 and is characterized by increased gonadotropin levels and decreased estradiol …