Residue-specific peptide modification: a chemist's guide
Advances in bioconjugation and native protein modification are appearing at a blistering
pace, making it increasingly time consuming for practitioners to identify the best chemical …
pace, making it increasingly time consuming for practitioners to identify the best chemical …
Advances in chemical protein modification
O Boutureira, GJL Bernardes - Chemical reviews, 2015 - ACS Publications
Chemical protein modification has emerged as an invaluable tool for the development of
modified proteins. The complementary use of both genetic and chemical methods has …
modified proteins. The complementary use of both genetic and chemical methods has …
Developments and recent advancements in the field of endogenous amino acid selective bond forming reactions for bioconjugation
O Koniev, A Wagner - Chemical Society Reviews, 2015 - pubs.rsc.org
Bioconjugation methodologies have proven to play a central enabling role in the recent
development of biotherapeutics and chemical biology approaches. Recent endeavours in …
development of biotherapeutics and chemical biology approaches. Recent endeavours in …
Decarboxylative alkylation for site-selective bioconjugation of native proteins via oxidation potentials
The advent of antibody–drug conjugates as pharmaceuticals has fuelled a need for reliable
methods of site-selective protein modification that furnish homogeneous adducts. Although …
methods of site-selective protein modification that furnish homogeneous adducts. Although …
Recent progress in enzymatic protein labelling techniques and their applications
Protein-based conjugates are valuable constructs for a variety of applications. Conjugation
of proteins to fluorophores is commonly used to study their cellular localization and the …
of proteins to fluorophores is commonly used to study their cellular localization and the …
Coumarin heterocyclic derivatives: chemical synthesis and biological activity
FG Medina, JG Marrero, M Macías-Alonso… - Natural product …, 2015 - pubs.rsc.org
Coumarin heterocyclic derivatives: chemical synthesis and biological activity - Natural Product
Reports (RSC Publishing) DOI:10.1039/C4NP00162A Royal Society of Chemistry View PDF …
Reports (RSC Publishing) DOI:10.1039/C4NP00162A Royal Society of Chemistry View PDF …
Chemo-and regioselective lysine modification on native proteins
Site-selective chemical conjugation of synthetic molecules to proteins expands their
functional and therapeutic capacity. Current protein modification methods, based on …
functional and therapeutic capacity. Current protein modification methods, based on …
Site-selective functionalization of methionine residues via photoredox catalysis
Bioconjugation technologies have revolutionized the practice of biology and medicine by
allowing access to novel biomolecular scaffolds. New methods for residue-selective …
allowing access to novel biomolecular scaffolds. New methods for residue-selective …
Recent advances in biocatalysis with chemical modification and expanded amino acid alphabet
The two main strategies for enzyme engineering, directed evolution and rational design,
have found widespread applications in improving the intrinsic activities of proteins. Although …
have found widespread applications in improving the intrinsic activities of proteins. Although …
Site-selective lysine conjugation methods and applications towards antibody–drug conjugates
M Haque, N Forte, JR Baker - Chemical Communications, 2021 - pubs.rsc.org
Site-selective protein modification is of significant interest in chemical biology research, with
lysine residues representing a particularly challenging target. Whilst lysines are popular for …
lysine residues representing a particularly challenging target. Whilst lysines are popular for …