The purpose of this review is to bridge the gap between earlier literature on striatal
cholinergic interneurons and mechanisms of microcircuit interaction demonstrated with the …

Giant, aspiny cholinergic interneurons (ChIs) have long been known to be key nodes in the
striatal circuitry controlling goal‐directed actions and habits. In recent years, new …

Motor control in the striatum is an orchestra played by various neuronal populations. Loss of
harmony due to dopamine deficiency is considered the primary pathological cause of the …

Striatal cholinergic interneurons, the so-called tonically active neurons (TANs), pause their
firing in response to sensory cues and rewards during classical conditioning and …

Improving exercise capacity during adolescence impacts positively on cognitive and motor
functions. However, the neural mechanisms contributing to enhance physical performance …

L-Dopa induced dyskinesia (LID) is a debilitating side effect of dopamine replacement
therapy for Parkinson's Disease. The mechanistic underpinnings of LID remain obscure …

A major advance in understanding learning behavior stems from experiments showing that
reward learning requires dopamine inputs to striatal neurons and arises from synaptic …

Our previous study showed that datumetine modulates NMDAR activity with long term
exposure leading to memory deficit and altered NMDAR signaling. We aim to explore the …

Pauses in the firing of tonically-active cholinergic interneurons (ChIs) in the striatum coincide
with phasic activation of dopamine neurons during reinforcement learning. However, how …

Mesencephalic dopamine neurons (DAN) signal motivation and reward prediction errors.
Their collective functions are considered critical for the translation of thought into context …