Molecular pathology of neurodegenerative diseases by cryo-EM of amyloids
Abnormal assembly of tau, α-synuclein, TDP-43 and amyloid-β proteins into amyloid
filaments defines most human neurodegenerative diseases. Genetics provides a direct link …
filaments defines most human neurodegenerative diseases. Genetics provides a direct link …
Amyloid oligomers: A joint experimental/computational perspective on Alzheimer's disease, Parkinson's disease, type II diabetes, and amyotrophic lateral sclerosis
PH Nguyen, A Ramamoorthy, BR Sahoo… - Chemical …, 2021 - ACS Publications
Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …
Challenges and hopes for Alzheimer's disease
SA Tatulian - Drug discovery today, 2022 - Elsevier
Recent drug development efforts targeting Alzheimer's disease (AD) have failed to produce
effective disease-modifying agents for many reasons, including the substantial …
effective disease-modifying agents for many reasons, including the substantial …
TRP (transient receptor potential) ion channel family: Structures, biological functions and therapeutic interventions for diseases
Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …
Half a century of amyloids: past, present and future
Amyloid diseases are global epidemics with profound health, social and economic
implications and yet remain without a cure. This dire situation calls for research into the …
implications and yet remain without a cure. This dire situation calls for research into the …
Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases
C Soto, S Pritzkow - Nature neuroscience, 2018 - nature.com
A hallmark event in neurodegenerative diseases (NDs) is the misfolding, aggregation, and
accumulation of proteins, leading to cellular dysfunction, loss of synaptic connections, and …
accumulation of proteins, leading to cellular dysfunction, loss of synaptic connections, and …
Amyloid-beta peptide and tau protein crosstalk in Alzheimer's disease
AR Roda, G Serra-Mir, L Montoliu-Gaya… - Neural regeneration …, 2022 - journals.lww.com
Alzheimer's disease is a neurodegenerative disease that accounts for most of the 50-million
dementia cases worldwide in 2018. A large amount of evidence supports the amyloid …
dementia cases worldwide in 2018. A large amount of evidence supports the amyloid …
A new era for understanding amyloid structures and disease
MG Iadanza, MP Jackson, EW Hewitt… - … reviews Molecular cell …, 2018 - nature.com
The aggregation of proteins into amyloid fibrils and their deposition into plaques and
intracellular inclusions is the hallmark of amyloid disease. The accumulation and deposition …
intracellular inclusions is the hallmark of amyloid disease. The accumulation and deposition …
A deep learning approach for automated diagnosis and multi-class classification of Alzheimer's disease stages using resting-state fMRI and residual neural networks
Alzheimer's disease (AD) is an incurable neurodegenerative disorder accounting for 70%–
80% dementia cases worldwide. Although, research on AD has increased in recent years …
80% dementia cases worldwide. Although, research on AD has increased in recent years …
Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease
Type I interferon (IFN) is a key cytokine that curbs viral infection and cell malignancy.
Previously, we demonstrated a potent IFN immunogenicity of nucleic acid–containing (NA …
Previously, we demonstrated a potent IFN immunogenicity of nucleic acid–containing (NA …