Recent evidence indicates that mitochondria lie at the heart of immunity. Mitochondrial DNA
acts as a danger-associated molecular pattern (DAMP), and the mitochondrial outer …

Recent advances in the field of immunometabolism support the concept that fundamental
processes in T cell biology, such as TCR-mediated activation and T helper lineage …

Abstract The oncometabolite (R)-2-hydroxyglutarate (R-2-HG) produced by isocitrate
dehydrogenase (IDH) mutations promotes gliomagenesis via DNA and histone methylation …

Rational design of chimeric antigen receptor T (CAR-T) cells based on the recognition of
antigenic epitopes capable of evoking the most potent CAR activation is an important …

Mitochondrial disease refers to a heterogeneous group of disorders resulting in defective
cellular energy production due to abnormal oxidative phosphorylation (oxphos). Primary …

Nitric oxide (NO) is a key messenger in the pathogenesis of inflammation, linking innate and
adaptive immunity. By targeting signaling molecules, NO from inducible NO synthase (iNOS) …

The aging process is accompanied by the onset of disease and a general decline in
wellness. Insights into the aging process have revealed a number of cellular hallmarks of …

T cells must migrate in order to encounter antigen-presenting cells (APCs) and to execute
their varied functions in immune defense and inflammation. ATP release and autocrine …

Initial T cell activation is triggered by the formation of highly dynamic, spatiotemporally
restricted Ca2+ microdomains. Purinergic signaling is known to be involved in Ca2+ influx in …

Polymorphonuclear neutrophils (PMNs) form the first line of defense against invading
microorganisms. We have shown previously that ATP release and autocrine purinergic …