Amyloid oligomers: A joint experimental/computational perspective on Alzheimer's disease, Parkinson's disease, type II diabetes, and amyotrophic lateral sclerosis
PH Nguyen, A Ramamoorthy, BR Sahoo… - Chemical …, 2021 - ACS Publications
Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …
Amyloid formation as a protein phase transition
The formation of amyloid fibrils is a general class of protein self-assembly behaviour, which
is associated with both functional biology and the development of a number of disorders …
is associated with both functional biology and the development of a number of disorders …
Endothelial leakiness elicited by amyloid protein aggregation
Alzheimer's disease (AD) is a major cause of dementia debilitating the global ageing
population. Current understanding of the AD pathophysiology implicates the aggregation of …
population. Current understanding of the AD pathophysiology implicates the aggregation of …
Anionic nanoplastic exposure induces endothelial leakiness
The global-scale production of plastics has been instrumental in advancing modern society,
while the rising accumulation of plastics in landfills, oceans, and anything in between has …
while the rising accumulation of plastics in landfills, oceans, and anything in between has …
Mitigation of amyloidosis with nanomaterials
Amyloidosis is a biophysical phenomenon of protein aggregation with biological and
pathogenic implications. Among the various strategies developed to date, nanomaterials …
pathogenic implications. Among the various strategies developed to date, nanomaterials …
Spontaneous formation of β-sheet nano-barrels during the early aggregation of Alzheimer's amyloid beta
Soluble low-molecular-weight oligomers formed during the early aggregation of amyloid
peptides have been hypothesized as a major toxic species of amyloidogenesis. Herein, we …
peptides have been hypothesized as a major toxic species of amyloidogenesis. Herein, we …
Computational insights into the cross-talk between medin and Aβ: implications for age-related vascular risk factors in Alzheimer's disease
The aggregation of medin forming aortic medial amyloid is linked to arterial wall
degeneration and cerebrovascular dysfunction. Elevated levels of arteriolar medin are …
degeneration and cerebrovascular dysfunction. Elevated levels of arteriolar medin are …
Exploring Peptido‐Nanocomposites in the Context of Amyloid Diseases
N Andrikopoulos, H Tang, Y Wang, X Liang… - Angewandte …, 2024 - Wiley Online Library
Therapeutic peptides are a major class of pharmaceutical drugs owing to their target‐
binding specificity as well as their versatility in inhibiting aberrant protein‐protein …
binding specificity as well as their versatility in inhibiting aberrant protein‐protein …
A framework of paracellular transport via nanoparticles‐induced endothelial leakiness
Nanomaterial‐induced endothelial leakiness (NanoEL) is an interfacial phenomenon
denoting the paracellular transport of nanoparticles that is pertinent to nanotoxicology …
denoting the paracellular transport of nanoparticles that is pertinent to nanotoxicology …
Molecular insights into the oligomerization dynamics and conformations of amyloidogenic and non-amyloidogenic amylin from discrete molecular dynamics …
The amyloid aggregation of human islet amyloid polypeptide (hIAPP) is associated with
pancreatic β-cell death in type 2 diabetes. The S20G substitution of hIAPP (hIAPP (S20G)) …
pancreatic β-cell death in type 2 diabetes. The S20G substitution of hIAPP (hIAPP (S20G)) …