Despite being the subject of extensive research and clinical trials, neuroblastoma remains a
major therapeutic challenge in pediatric oncology. The p53 protein is a central safeguard …

Cancer is a main culprit and the second-leading cause of death worldwide. The current
mode of treatment strategies including surgery with chemotherapy and radiation therapy …

Abstract β-Carboline alkaloids are a family of natural and synthetic products with structural
diversity and outstanding antitumor activities. This review summarizes research …

Targeting cancer hallmarks is a cardinal strategy to improve antineoplastic treatment.
However, cross-talk between signaling pathways and key oncogenic processes frequently …

The canonical Wingless-related integration site signaling pathway plays a critical role in
human physiology, and its dysregulation can lead to an array of diseases. β-Catenin is a …

Most well studied as proteins that restrain the p53 tumor suppressor protein, MDM2 and
MDMX have rich lives outside of their relationship to p53. There is much to learn about how …

Multidrug resistance (MDR) of tumor cells to chemotherapeutic agents is the main reason for
the failure of cancer chemotherapy. Overexpression of ABCB1 transporter that actively …

The mutations and deregulation of Wnt signaling pathway occur commonly in human cancer
and cause the aberrant activation of β-catenin and β-catenin-dependent transcription, thus …

Gastric cancer is a common type of malignant tumor with a relatively poor prognosis and
presents a serious threat to global health. Signal Transducer and Activator of Transcription-3 …

The ubiquitin-proteasome system (UPS) is a fundamental regulatory mechanism in cells,
vital for maintaining cellular homeostasis, compiling signaling transduction, and determining …