Phase separation in immune signalling
Immune signalling pathways convert pathogenic stimuli into cytosolic events that lead to the
resolution of infection. Upon ligand engagement, immune receptors together with their …
resolution of infection. Upon ligand engagement, immune receptors together with their …
[HTML][HTML] Liquid-liquid phase separation: Orchestrating cell signaling through time and space
Cell signaling is a complex process. The faithful transduction of information into specific
cellular actions depends on the synergistic effects of many regulatory molecules, nurtured by …
cellular actions depends on the synergistic effects of many regulatory molecules, nurtured by …
Mechanistic dissection of increased enzymatic rate in a phase-separated compartment
W Peeples, MK Rosen - Nature chemical biology, 2021 - nature.com
Biomolecular condensates concentrate macromolecules into discrete cellular foci without an
encapsulating membrane. Condensates are often presumed to increase enzymatic reaction …
encapsulating membrane. Condensates are often presumed to increase enzymatic reaction …
Coupling of protein condensates to ordered lipid domains determines functional membrane organization
During T cell activation, the transmembrane adaptor protein LAT (linker for activation of T
cells) forms biomolecular condensates with Grb2 and Sos1, facilitating signaling. LAT has …
cells) forms biomolecular condensates with Grb2 and Sos1, facilitating signaling. LAT has …
Membrane surfaces regulate assembly of ribonucleoprotein condensates
Biomolecular condensates organize biochemistry, yet little is known about how cells control
the position and scale of these structures. In cells, condensates often appear as relatively …
the position and scale of these structures. In cells, condensates often appear as relatively …
Protein phase separation and its role in tumorigenesis
Cancer is a disease characterized by uncontrolled cell proliferation, but the precise
pathological mechanisms underlying tumorigenesis often remain to be elucidated. In recent …
pathological mechanisms underlying tumorigenesis often remain to be elucidated. In recent …
Macromolecular crowding, phase separation, and homeostasis in the orchestration of bacterial cellular functions
Macromolecular crowding affects the activity of proteins and functional macromolecular
complexes in all cells, including bacteria. Crowding, together with physicochemical …
complexes in all cells, including bacteria. Crowding, together with physicochemical …
Synergistic phase separation of two pathways promotes integrin clustering and nascent adhesion formation
Integrin adhesion complexes (IACs) are integrin-based plasma-membrane-associated
compartments where cells sense environmental cues. The physical mechanisms and …
compartments where cells sense environmental cues. The physical mechanisms and …
Physical constraints and forces involved in phagocytosis
V Jaumouillé, CM Waterman - Frontiers in immunology, 2020 - frontiersin.org
Phagocytosis is a specialized process that enables cellular ingestion and clearance of
microbes, dead cells and tissue debris that are too large for other endocytic routes. As such …
microbes, dead cells and tissue debris that are too large for other endocytic routes. As such …
Cell–cell interfaces as specialized compartments directing cell function
Cell–cell interfaces are found throughout multicellular organisms, from transient interactions
between motile immune cells to long-lived cell–cell contacts in epithelia. Studies of immune …
between motile immune cells to long-lived cell–cell contacts in epithelia. Studies of immune …