Telomere elongation chooses TERRA ALTernatives
R Arora, CM Azzalin - RNA biology, 2015 - Taylor & Francis
Alternative Lengthening of Telomeres (ALT) mechanisms allow telomerase-negative
immortal cells to buffer replicative telomere shortening. ALT is naturally active in a number of …
immortal cells to buffer replicative telomere shortening. ALT is naturally active in a number of …
The crosstalk of telomere dysfunction and inflammation through cell-free TERRA containing exosomes
Z Wang, PM Lieberman - RNA biology, 2016 - Taylor & Francis
Telomeric repeats-containing RNA (TERRA) are telomere-derived non-coding RNAs that
contribute to telomere function in protecting chromosome ends. We recently identified a cell …
contribute to telomere function in protecting chromosome ends. We recently identified a cell …
Repetitive DNA loci and their modulation by the non-canonical nucleic acid structures R-loops and G-quadruplexes
AC Hall, LA Ostrowski, V Pietrobon, K Mekhail - Nucleus, 2017 - Taylor & Francis
Cells have evolved intricate mechanisms to maintain genome stability despite allowing
mutational changes to drive evolutionary adaptation. Repetitive DNA sequences, which …
mutational changes to drive evolutionary adaptation. Repetitive DNA sequences, which …
Sex-specific variation in R-loop formation in Drosophila melanogaster
TJ Stanek, W Cao, RM Mehra, CE Ellison - PLoS genetics, 2022 - journals.plos.org
R-loops are three-stranded nucleotide structures consisting of a DNA: RNA hybrid and a
displaced ssDNA non-template strand. Previous work suggests that R-loop formation is …
displaced ssDNA non-template strand. Previous work suggests that R-loop formation is …
Telomere biology: Rationale for diagnostics and therapeutics in cancer
P Rousseau, C Autexier - RNA biology, 2015 - Taylor & Francis
The key step of carcinogenesis is the malignant transformation which is fundamentally a
telomere biology dysfunction permitting cells to bypass the Hayflick limit and to divide …
telomere biology dysfunction permitting cells to bypass the Hayflick limit and to divide …