The cancer burden continues to grow globally, and drug resistance remains a substantial
challenge in cancer therapy. It is well established that cancerous cells with clonal dysplasia …

High-grade gliomas (HGGs) are lethal central nervous system tumors that spread quickly
through the brain, making treatment challenging. Integrins are transmembrane receptors that …

Despite numerous molecular targeted therapies tested in glioblastoma (GBM), no significant
progress in patient survival has been achieved in the last 20 years in the overall population …

Glioblastomas (GBM) are the most common primary brain tumors in adults and associated
with poor clinical outcomes due to therapy resistances and destructive growth. Interactions …

A relevant challenge for the treatment of patients with neoplasia is the development of
resistance to chemo-, immune-, and radiotherapies. Although the causes of therapy …

Integrins are well-characterized receptors involved in cell adhesion and signaling. With six
approved drugs, they are recognized as valuable therapeutic targets. Here, we explore …

We present GBM-cRegMap, an online resource providing a comprehensive coregulatory
influence network perspective on glioblastoma (GBM) heterogeneity and plasticity. Using …

Temozolomide (TMZ) stands as the primary chemotherapy choice for glioblastoma
multiforme (GBM), yet resistance frequently emerges in patients, leading to tumor recurrence …