Harnessing Sulforaphane Potential as a Chemosensitizing Agent: A Comprehensive Review

BL Sailo, L Liu, S Chauhan, S Girisa, M Hegde, L Liang… - Cancers, 2024 - mdpi.com
Simple Summary Recent oncological research highlights the promising role of naturally
derived compounds in cancer prevention and treatment. Sulforaphane (SFN), a …

Metabolism, absorption, and anti-cancer effects of sulforaphane: An update

H Gu, X Mao, M Du - Critical Reviews in Food Science and …, 2022 - Taylor & Francis
Cancer is one of the most devastating diseases, and recently, a variety of natural
compounds with preventive effects on cancer developments have been reported …

Sulforaphane inhibits the expression of interleukin-6 and interleukin-8 induced in bronchial epithelial IB3-1 cells by exposure to the SARS-CoV-2 Spike protein

J Gasparello, E D'Aversa, C Papi, L Gambari, B Grigolo… - Phytomedicine, 2021 - Elsevier
Background A key clinical feature of COVID-19 is a deep inflammatory state known as
“cytokine storm” and characterized by high expression of several cytokines, chemokines and …

Treatment of human glioblastoma U251 cells with sulforaphane and a peptide nucleic acid (PNA) targeting miR-15b-5p: synergistic effects on induction of apoptosis

J Gasparello, C Papi, M Zurlo, L Gambari, A Rozzi… - Molecules, 2022 - mdpi.com
Glioblastoma multiforme (GBM) is a lethal malignant tumor accounting for 42% of the tumors
of the central nervous system, the median survival being 15 months. At present, no curative …

A distinctive microRNA (miRNA) signature in the blood of colorectal cancer (CRC) patients at surgery

J Gasparello, C Papi, M Allegretti, E Giordani… - Cancers, 2020 - mdpi.com
Background: Liquid biopsy (LB) provides an examination of the peripheral blood of cancer
patients for circulating tumor cells, cell-free nucleic acids and microRNAs (miRNAs) and is …

Peptide nucleic acids and their role in gene regulation and editing

JDR Perera, KEW Carufe, PM Glazer - Biopolymers, 2021 - Wiley Online Library
The unique properties of peptide nucleic acid (PNA) makes it a desirable candidate to be
used in therapeutic and biotechnological interventions. It has been broadly utilized for …

Comprehensive Insights Into the Combinatorial Uses of Selected Phytochemicals in Colorectal Cancer Prevention and Treatment: Isothiocyanates, Quinones …

X Deng, Z Yang, M Han, N Ismail, NM Esa… - Phytotherapy …, 2024 - Wiley Online Library
Despite the advancement in cancer diagnosis and treatment, colorectal cancer remains the
leading cause of cancer‐related death worldwide. Given the high recurrence rate of …

A comprehensive review on function of miR-15b-5p in malignant and non-malignant disorders

S Ghafouri-Fard, T Khoshbakht, BM Hussen… - Frontiers in …, 2022 - frontiersin.org
miR-15b-5p is encoded by MIR15B gene. This gene is located on cytogenetic band 3q25.
33. This miRNA participates in the pathogenesis of several cancers as well as non …

MicroRNAs miR-584-5p and miR-425-3p are up-regulated in plasma of colorectal cancer (CRC) patients: Targeting with inhibitor peptide nucleic acids is associated …

J Gasparello, C Papi, M Zurlo, L Gambari, A Manicardi… - Cancers, 2022 - mdpi.com
Simple Summary Starting from a list of nine miRNAs found to be dysregulated in the
bloodstream of early-stage colon cancer (CRC) patients, the biological effects of the …

Nutritional combinatorial impact on the gut microbiota and plasma short-chain fatty acids levels in the prevention of mammary cancer in Her2/neu estrogen receptor …

M Sharma, I Arora, ML Stoll, Y Li, CD Morrow… - PLoS …, 2020 - journals.plos.org
Breast cancer is the second leading cause of cancer-related mortality in women. Various
nutritional compounds possess anti-carcinogenic properties which may be mediated …