Background The marine environment hosts a wide variety of species that have evolved to
live in harsh and challenging conditions. Marine organisms are the focus of interest due to …

The growing resistance of microorganisms towards antibiotics has become a serious global
problem. Therapeutics with novel chemical scaffolds and/or mechanisms of action are …

The use of fertilizers and chemical pesticides promotes significant improvements in crop
development, but some problems and risks associated with them limit their application. An …

Cancer stands in the frontline among leading killers worldwide and the annual mortality rate
is expected to reach 16.4 million by 2040. Humans suffer from about 200 different types of …

[4+ 2]-Cycloadditions are increasingly being recognized in the biosynthetic pathways of
many structurally complex natural products. A relatively small collection of enzymes from …

Endophytic actinomycetes are a promising source of novel metabolites with diverse
biological activities. Tea plants (Camellia sinensis) produce arsenals of phytochemicals …

Covering: up to mid-2014 Over the last several decades, the number of pharmacologically
active natural products has significantly increased and several natural product families have …

The discovery of chlorothricin (1) defined a new family of microbial metabolites with potent
antitumor antibiotic properties collectively referred to as spirotetronate polyketides. These …

Secondary metabolites of microbial origin are structurally diverse and functionally versatile
compounds that offer selective advantages to the producing organism. Production of these …

In the course of a screening program for bioactive compounds from a marine natural product
library, a newly isolated Actinomycetes strain, designated as MS100061, exhibited strong …