Cyclic fasting-mimicking diet in cancer treatment: Preclinical and clinical evidence

C Vernieri, F Ligorio, D Tripathy, VD Longo - Cell metabolism, 2024 - cell.com
In preclinical tumor models, cyclic fasting and fasting-mimicking diets (FMDs) produce
antitumor effects that become synergistic when combined with a wide range of standard …

Nutrition and dietary restrictions in cancer prevention

A Mishra, G Giuliani, VD Longo - … et Biophysica Acta (BBA)-Reviews on …, 2024 - Elsevier
The composition and pattern of dietary intake have emerged as key factors influencing
aging, regeneration, and consequently, healthspan and lifespan. Cancer is one of the major …

The potential of fasting-mimicking diet as a preventive and curative strategy for Alzheimer's disease

V Boccardi, M Pigliautile, AG Guazzarini, P Mecocci - Biomolecules, 2023 - mdpi.com
This review examines the potential of fasting-mimicking diets (FMDs) in preventing and
treating Alzheimer's disease (AD). FMDs are low-calorie diets that mimic the physiological …

The effects of dietary interventions on brain aging and neurological diseases

F Lobo, J Haase, S Brandhorst - Nutrients, 2022 - mdpi.com
Dietary interventions can ameliorate age-related neurological decline. Decades of research
of in vitro studies, animal models, and clinical trials support their ability and efficacy to …

Intermittent fasting and longevity: From animal models to implication for humans

O Strilbytska, S Klishch, KB Storey, A Koliada… - Ageing research …, 2024 - Elsevier
In recent years, intermittent fasting (IF) and its numerous modifications have been
increasingly suggested as a promising therapy for age-related problems and a non …

Intermittent fasting, fatty acid metabolism reprogramming, and neuroimmuno microenvironment: mechanisms and application prospects

A Zhang, J Wang, Y Zhao, Y He, N Sun - Frontiers in Nutrition, 2024 - frontiersin.org
Intermittent fasting (IF) has demonstrated extensive health benefits through the regulation of
fatty acid metabolism and modulation of the neuroimmune microenvironment, primarily via …

Effects of the periodic fasting-mimicking diet on health, lifespan, and multiple diseases: A narrative review and clinical implications

R Wang, X Lv, W Xu, X Li, X Tang, H Huang… - Nutrition …, 2025 - academic.oup.com
Dietary restriction and fasting have been recognized for their beneficial effects on health and
lifespan and their potential application in managing chronic metabolic diseases. However …

Fasting-mimicking diet alleviates inflammatory pain by inhibiting neutrophil extracellular traps formation and neuroinflammation in the spinal cord

T Li, Y Yue, Y Ma, Z Zhong, M Guo, J Zhang… - Cell Communication and …, 2023 - Springer
Abstract Background Neutrophil extracellular traps (NETs) promote neuroinflammation and,
thus, central nervous system (CNS) disease progression. However, it remains unclear …

A kidney-specific fasting-mimicking diet induces podocyte reprogramming and restores renal function in glomerulopathy

V Villani, CN Frank, P Cravedi, X Hou, S Bin… - Science Translational …, 2024 - science.org
Cycles of a fasting-mimicking diet (FMD) promote regeneration and reduce damage in the
pancreases, blood, guts, and nervous systems of mice, but their effect on kidney disease is …

Geroprotective interventions in the 3xTg mouse model of Alzheimer's disease

MM Sonsalla, DW Lamming - Geroscience, 2023 - Springer
Alzheimer's disease (AD) is an age-associated neurodegenerative disease. As the
population ages, the increasing prevalence of AD threatens massive healthcare costs in the …