Nitrogenase is the only enzyme capable of reducing N2 to NH3. This challenging reaction
requires the coordinated transfer of multiple electrons from the reductase, Fe-protein, to the …

Actin is the most abundant protein in most eukaryotic cells. It is highly conserved and
participates in more protein-protein interactions than any known protein. These properties …

Abstract CHARMM (Chemistry at HARvard Molecular Mechanics) is a highly versatile and
widely used molecular simulation program. It has been developed over the last three …

Decreased cardiac contractility is a central feature of systolic heart failure. Existing drugs
increase cardiac contractility indirectly through signaling cascades but are limited by their …

The major function of vascular smooth muscle cells (SMCs) is contraction to regulate blood
pressure and flow. SMC contractile force requires cyclic interactions between SMC α-actin …

The interaction of myosin with actin filaments is the central feature of muscle contraction and
cargo movement along actin filaments of the cytoskeleton. The energy for these movements …

Actin plays crucial parts in cell motility through a dynamic process driven by polymerization
and depolymerization, that is, the globular (G) to fibrous (F) actin transition. Although our …

Regulation of myosin and filamentous actin interaction by tropomyosin is a central feature of
contractile events in muscle and nonmuscle cells. However, little is known about molecular …

As myofibrils consist of a three-dimensional network of long, solid protein particles with the
shortest dimension of less than 20nm, the theoretical foundations of water-holding in meat …

F-actin is a helical assembly of actin, which is a component of muscle fibres essential for
contraction and has a crucial role in numerous cellular processes, such as the formation of …