Nasal allergen challenge (NAC) is an important tool to diagnose allergic rhinitis. In daily
clinical routine, experimentally, or when measuring therapeutic success clinically, nasal …

Nasal and ocular challenges facilitate the evaluation of subjective and objective responses
to defined allergen or irritant exposure. Nasal and ocular allergen challenges are the gold …

Introduction Allergen-specific immunotherapy (AIT) is the only disease-modifying treatment
option for allergic rhinitis (AR) patients with persistent moderate-severe AR for whom …

Abstract Background The Nasal Allergen Challenge (NAC) model allows the study of
Allergic Rhinitis (AR) pathophysiology and the proof of concept of novel therapies. The …

Nasal allergen challenge (NAC) is applied in a variety of settings (research centers,
specialty clinics, and hospitals) as a useful diagnostic and research tool. NAC is indicated …

Background Epigenetic alterations may represent new therapeutic targets and/or biomarkers
of allergic rhinitis (AR). Our aim was to examine genome‐wide epigenetic changes induced …

Background The direct-instillation nasal allergen challenge (NAC) and the environmental
exposure chamber (EEC) are 2 methods of conducting controlled allergen provocations. The …

Objective To summarize studies highlighting recent advances in rhinitis-related research in
the past 2 years. Data Sources Original research articles were procured and examined from …

Abstract Background The Environmental Exposure Unit (EEU) in Kingston, Ontario, Canada
is a controlled allergen challenge facility (CACF) that has been previously clinically …

Purpose It remains unknown whether allergen-specific immunotherapy (AIT) could attenuate
airway inflammatory response triggered by allergen exposure. Methods We performed …