Inter-organ crosstalk during development and progression of type 2 diabetes mellitus

G Xourafa, M Korbmacher, M Roden - Nature Reviews Endocrinology, 2024 - nature.com
Type 2 diabetes mellitus (T2DM) is characterized by tissue-specific insulin resistance and
pancreatic β-cell dysfunction, which result from the interplay of local abnormalities within …

Precision medicine for cardiometabolic disease: a framework for clinical translation

PW Franks, WT Cefalu, J Dennis, JC Florez… - The Lancet Diabetes & …, 2023 - thelancet.com
Cardiometabolic disease is a major threat to global health. Precision medicine has great
potential to help to reduce the burden of this common and complex disease cluster, and to …

Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals

F Asnicar, SE Berry, AM Valdes, LH Nguyen… - Nature medicine, 2021 - nature.com
The gut microbiome is shaped by diet and influences host metabolism; however, these links
are complex and can be unique to each individual. We performed deep metagenomic …

Noninvasive proteomic biomarkers for alcohol-related liver disease

L Niu, M Thiele, PE Geyer, DN Rasmussen… - Nature Medicine, 2022 - nature.com
Alcohol-related liver disease (ALD) is a major cause of liver-related death worldwide, yet
understanding of the three key pathological features of the disease—fibrosis, inflammation …

SWOT analysis of noninvasive tests for diagnosing NAFLD with severe fibrosis: an expert review by the JANIT Forum

Y Kamada, T Nakamura, S Isobe, K Hosono… - Journal of …, 2023 - Springer
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease.
Nonalcoholic steatohepatitis (NASH) is an advanced form of NAFLD can progress to liver …

[HTML][HTML] Artificial intelligence applications in hepatology

JM Schattenberg, N Chalasani, N Alkhouri - Clinical Gastroenterology and …, 2023 - Elsevier
Over the past 2 decades, the field of hepatology has witnessed major developments in
diagnostic tools, prognostic models, and treatment options making it one of the most …

Comparison and development of advanced machine learning tools to predict nonalcoholic fatty liver disease: An extended study

YX Liu, X Liu, C Cen, X Li, JM Liu, ZY Ming… - … & Pancreatic Diseases …, 2021 - Elsevier
Background Nonalcoholic fatty liver disease (NAFLD) is a public health challenge and
significant cause of morbidity and mortality worldwide. Early identification is crucial for …

Fasting plasma GLP-1 is associated with overweight/obesity and cardiometabolic risk factors in children and adolescents

SE Stinson, AE Jonsson, MAV Lund… - The Journal of …, 2021 - academic.oup.com
Context The importance of fasting glucagon-like peptide-1 (GLP-1) in altered metabolic
outcomes has been questioned. Objective This work aimed to assess whether fasting GLP-1 …

Ethanol extract of licorice alleviates HFD-induced liver fat accumulation in association with modulation of gut microbiota and intestinal metabolites in obesity mice

F Liu, X Tang, B Mao, Q Zhang, J Zhao, S Cui, W Chen - Nutrients, 2022 - mdpi.com
As a traditional Chinese medicine, licorice is often used in functional foods for its health
benefits. However, the role of gut microbiota in the efficacy of licorice has not yet been fully …

Machine Learning‐Based Prediction Model of Preterm Birth Using Electronic Health Record

Q Sun, X Zou, Y Yan, H Zhang, S Wang… - Journal of …, 2022 - Wiley Online Library
Objective. Preterm birth (PTB) was one of the leading causes of neonatal death. Predicting
PTB in the first trimester and second trimester will help improve pregnancy outcomes. The …