Poly (ethylene glycol) alternatives in biomedical applications

X Yao, C Qi, C Sun, F Huo, X Jiang - Nano Today, 2023 - Elsevier
Abstract Poly (ethylene glycol)(PEG) as gold standard has been extensively conjugated to
diagnostic and therapeutic agents or decorated on the surface of nanoplatforms, which is …

Host defense peptide mimicking antimicrobial amino acid polymers and beyond: Design, synthesis and biomedical applications

Y Wu, K Chen, J Wang, M Chen, Y Chen, Y She… - Progress in Polymer …, 2023 - Elsevier
Microbial infections endanger human health and life. Conventional antibiotics has saved
countless human lives, however, is seriously challenged by the quick emergence of …

Efficient Synthesis of N-Methyl Polypeptides by Organic Acid Promoted Controlled Ring-Opening Polymerization of N-Methyl-α-Amino Acids N-Carboxyanhydrides

X Yu, Y Wang, Y Dong, N Zhao, L Zhang, S Xuan… - …, 2023 - ACS Publications
N-Methyl peptides, which are widely found in nature, have emerged as an intriguing material
in both polymer science and the biomedical field. The inefficient synthesis of N-methyl …

Ring-Opening Polymerization of Amino Acid N-Carboxyanhydrides with Unprotected/Reactive Side Groups. I. d-Penicillamine N-Carboxyanhydride

S Wang, H Lu - ACS Macro Letters, 2023 - ACS Publications
The ring-opening (co) polymerization (ROP) of N-carboxyanhydride (NCA) monomers
bearing unprotected/reactive side groups is rare and challenging. Here, we report the ROP …

Precision Synthesis of Polysarcosine via Controlled Ring-Opening Polymerization of N-Carboxyanhydride: Fast Kinetics, Ultrahigh Molecular Weight, and …

S Wang, MY Lu, SK Wan, CY Lyu, ZY Tian… - Journal of the …, 2024 - ACS Publications
The rapid and controlled synthesis of high-molecular-weight (HMW) polysarcosine (pSar), a
potential polyethylene glycol (PEG) alternative, via the ring-opening polymerization (ROP) of …

Biodegradable polysarcosine with inserted alanine residues: Synthesis and enzymolysis

P Zhou, T Shen, W Chen, J Sun, J Ling - Biomacromolecules, 2022 - ACS Publications
Polysarcosine (PSar), a water-soluble polypeptoid, is gifted with biodegradability via the
random ring-opening copolymerization of sarcosine-and alanine-N-thiocarboxyanhydrides …

[HTML][HTML] A Review on the Synthesis of Polypeptoids

Z Qiu, M Zhang, D Liu, X Shen, W Zhou, W Liu, J Lu… - Catalysts, 2023 - mdpi.com
Polyeptoids are a promising class of polypeptide mimetic biopolymers based on N-
substituted glycine backbones. Because of the high designability of their side chains …

A field guide to optimizing peptoid synthesis

AM Clapperton, J Babi, H Tran - ACS Polymers Au, 2022 - ACS Publications
N-Substituted glycines (peptoids) are a class of peptidomimetic molecules used as materials
for health, environmental, and drug delivery applications. Automated solid-phase synthesis …

An inspection into multifarious ways to synthesize poly (amino acid) s

B Zheng, T Bai, X Tao, J Ling - Macromolecular Rapid …, 2021 - Wiley Online Library
Poly (α‐amino acid) s (PAAs) attract growing attention due to their essential role in the
application as biomaterials. To synthesize PAAs with desired structures and properties …

Glycine N-Thiocarboxyanhydride: A Key to Glycine-Rich Protein Mimics

J Wang, P Zhou, T Shen, S Xu, T Bai, J Ling - ACS Macro Letters, 2023 - ACS Publications
Glycine-rich proteins (GRPs) containing a high content of glycine residues (> 30%) possess
unique structural stability. However, the controllable synthesis of glycine-rich poly (amino …