Factor XIa (FXIa) in the intrinsic pathway of the coagulation process has been proven to be
an effective and safe target for anticoagulant discovery with limited or no bleeding …

Abstract Factor XIa (FXIa) is a serine protease homodimer that belongs to the intrinsic
coagulation pathway. FXIa primarily catalyzes factor IX activation to factor IXa, which …

Inhibitors of mutant isocitrate dehydrogenase (mIDH) 1 and 2 cancer-associated enzymes
prevent the accumulation of the oncometabolite d-2-hydroxyglutarate (2-HG) and are under …

The use of nanoparticles (NPs) in biomedicine has made a gradual transition from proof-of-
concept to clinical applications, with several NP types meeting regulatory approval or …

Biological systems are highly regulated. They are also highly resistant to sudden
perturbations enabling them to maintain the dynamic equilibrium essential to sustain life …

This comprehensive review addresses the intricate and multifaceted regulation of peptidase
activity in human health and disease, providing a comprehensive investigation that extends …

The catalytic activity of enzymes can be regulated by interactions with synthetic
nanoparticles (NPs) in a number of ways. To date, however, the potential use of NPs as …

Abstract Condensation of 7-hydroxy-1, 2, 2, 4-tetramethylhydroquinoline-6-carbaldehydes
with various hetaryl-substituted 3-oxo esters afforded a series of hybrid hydro-6, 8, 8, 9 …

Abstract Background Human factor XIa (FXIa) is an actively pursued target for development
of safer anticoagulants. Our long‐standing hypothesis has been that allosterism originating …

Enzymes are an important class of biomacromolecules which catalyze many metabolic
processes in living systems. Nanomaterials can be synthesized with tailored sizes as well as …