Recent advances in systems and synthetic biology approaches for developing novel cell-factories in non-conventional yeasts

P Patra, M Das, P Kundu, A Ghosh - Biotechnology Advances, 2021 - Elsevier
Microbial bioproduction of chemicals, proteins, and primary metabolites from cheap carbon
sources is currently an advancing area in industrial research. The model yeast …

Multiscale models quantifying yeast physiology: towards a whole-cell model

H Lu, EJ Kerkhoven, J Nielsen - Trends in Biotechnology, 2022 - cell.com
The yeast Saccharomyces cerevisiae is widely used as a cell factory and as an important
eukaryal model organism for studying cellular physiology related to human health and …

Reconstruction of a Genome-Scale Metabolic Model of Scenedesmus obliquus and Its Application for Lipid Production under Three Trophic Modes

A Ray, P Kundu, A Ghosh - ACS Synthetic Biology, 2023 - ACS Publications
Green microalgae have emerged as beneficial feedstocks for biofuel production. A systems-
level understanding of the biochemical network is needed to harness the microalgal …

Metagenome-scale community metabolic modelling for understanding the role of gut microbiota in human health

S Beura, P Kundu, AK Das, A Ghosh - Computers in biology and medicine, 2022 - Elsevier
Metabolic activities of the microbial population are important to maintain the balance of
almost all the ecosystems on earth. In the human gut environment, these microbial …

Unveiling the potential of systems biology in biotechnology and biomedical research

S Saranya, L Thamanna, P Chellapandi - Systems Microbiology and …, 2024 - Springer
Abstract “In silico organisms” are computational genome-scale metabolic models used in
systems and synthetic biology developed by constraint-based metabolic simulations using …

A genome-informed higher rank classification of the biotechnologically important fungal subphylum Saccharomycotina

M Groenewald, CT Hittinger, K Bensch… - Studies in …, 2023 - ingentaconnect.com
The subphylum Saccharomycotina is a lineage in the fungal phylum Ascomycota that
exhibits levels of genomic diversity similar to those of plants and animals. The …

Non-conventional yeasts for food and additives production in a circular economy perspective

RL Binati, E Salvetti, A Bzducha-Wróbel… - FEMS Yeast …, 2021 - academic.oup.com
Yeast species have been spontaneously participating in food production for millennia, but
the scope of applications was greatly expanded since their key role in beer and wine …

How reliable are Chinese hamster ovary (CHO) cell genome‐scale metabolic models?

B Strain, J Morrissey, A Antonakoudis… - Biotechnology and …, 2023 - Wiley Online Library
Genome‐scale metabolic models (GEMs) possess the power to revolutionize bioprocess
and cell line engineering workflows thanks to their ability to predict and understand whole …

Vitreoscilla Haemoglobin: A Tool to Reduce Overflow Metabolism

H Taymaz-Nikerel, AR Lara - Microorganisms, 2021 - mdpi.com
Overflow metabolism is a phenomenon extended in nature, ranging from microbial to cancer
cells. Accumulation of overflow metabolites pose a challenge for large-scale bioprocesses …

Genome-scale model of Rothia mucilaginosa predicts gene essentialities and reveals metabolic capabilities

N Leonidou, L Ostyn, T Coenye, A Crabbé… - Microbiology …, 2024 - Am Soc Microbiol
Cystic fibrosis (CF), an inherited genetic disorder caused by mutations in the cystic fibrosis
transmembrane conductance regulator gene, results in sticky and thick mucosal fluids. This …