Insights into the pathophysiology of Alzheimer's disease and potential therapeutic targets: A current perspective

K Rajah Kumaran, S Yunusa, E Perimal… - Journal of …, 2023 - content.iospress.com
The aging population increases steadily because of a healthy lifestyle and medical
advancements in healthcare. However, Alzheimer's disease (AD) is becoming more …

IgM natural autoantibodies in physiology and the treatment of disease

M Fereidan-Esfahani, T Nayfeh, A Warrington… - … Antibodies: Methods and …, 2019 - Springer
Antibodies are vital components of the adaptive immune system for the recognition and
response to foreign antigens. However, some antibodies recognize self-antigens in healthy …

Comparison of fractal and grid electrodes for studying the effects of spatial confinement on dissociated retinal neuronal and glial behavior

S Moslehi, C Rowland, JH Smith, W Griffiths… - Scientific Reports, 2022 - nature.com
Understanding the impact of the geometry and material composition of electrodes on the
survival and behavior of retinal cells is of importance for both fundamental cell studies and …

[HTML][HTML] DNA aptamers that modulate biological activity of model neurons

J Rolli, K Pearson, B Wilbanks, SCL Hrstka… - … Therapy Nucleic Acids, 2024 - cell.com
There is an urgent need for agents that promote health and regeneration of cells and
tissues, specifically to treat diseases of the aging nervous system. Age-associated nervous …

[HTML][HTML] The Emerging Role of Immunoglobulins and Complement in the Stimulation of Neuronal Activity and Repair: Not as Simple as We Thought

T Veremeyko, NS Barteneva, I Vorobyev… - Biomolecules, 2024 - mdpi.com
Neurologic disorders such as traumatic brain injury, multiple sclerosis, Alzheimer's disease,
and drug-resistant epilepsy have a high socioeconomic impact around the world. Current …

Human-derived natural antibodies: biomarkers and potential therapeutics

X Xu, SM Ng, E Hassouna, A Warrington, SH Oh… - Future …, 2015 - Taylor & Francis
The immune system generates antibodies and antigen-specific T-cells as basic elements of
the immune networks that differentiate self from non-self in a finely tuned manner. The …

Applications of SPR for the characterization of molecules important in the pathogenesis and treatment of neurodegenerative diseases

NJ Wittenberg, B Wootla, LR Jordan… - Expert review of …, 2014 - Taylor & Francis
Characterization of binding kinetics and affinity between a potential drug and its receptor are
key steps in the development of new drugs. Among the techniques available to determine …

A comparison of human natural monoclonal antibodies and aptamer conjugates for promotion of CNS remyelination: where are we now and what comes next?

MK Perwein, JA Smestad, AE Warrington… - Expert Opinion on …, 2018 - Taylor & Francis
Introduction: Multiple sclerosis (MS) is a chronic and progressive inflammatory
demyelinating disease of the human central nervous system (CNS) and is the most common …

Naturally occurring monoclonal antibodies and their therapeutic potential for neurologic diseases

B Wootla, JO Watzlawik, AE Warrington… - JAMA …, 2015 - jamanetwork.com
Importance Modulating the immune system does not reverse long-term disability in
neurologic disorders. Better neuroregenerative and neuroprotective treatment strategies are …

Protein micropatterns printed on glass: Novel tools for protein‐ligand binding assays in live cells

C Dirscherl, S Springer - Engineering in Life Sciences, 2018 - Wiley Online Library
Micrometer‐sized patterns of proteins on glass or silica surfaces are in widespread use as
protein arrays for probing with ligands or recombinant proteins. More recently, they have …