The use of RNA-based treatments in the field of cancer immunotherapy

M Chehelgerdi, M Chehelgerdi - Molecular Cancer, 2023 - Springer
Over the past several decades, mRNA vaccines have evolved from a theoretical concept to a
clinical reality. These vaccines offer several advantages over traditional vaccine techniques …

The ArcAB two-component system: function in metabolism, redox control, and infection

AN Brown, MT Anderson, MA Bachman… - Microbiology and …, 2022 - Am Soc Microbiol
ArcAB, also known as the Arc system, is a member of the two-component system family of
bacterial transcriptional regulators and is composed of sensor kinase ArcB and response …

Environmental adaptation and diversification of bacterial two-component systems

AF Alvarez, D Georgellis - Current Opinion in Microbiology, 2023 - Elsevier
Bacterial two-component systems (TCS) are versatile signaling mechanisms that govern
cellular responses to diverse environmental cues. These systems rely on phosphoryl-group …

Chemical pretreatments and anaerobic digestion shape the virome and functional microbiome in fecal sludge

H Cui, J Wang, X Cai, K Feng, GJ Xie… - Environmental …, 2023 - ACS Publications
The decomposition and pathogen inactivation of fecal sludge (FS) are vitally important for
safely managing onsite sanitation and protecting public and environmental health. However …

S-Nitrosylation of the virulence regulator AphB promotes Vibrio cholerae pathogenesis

J Chen, H Byun, Q She, Z Liu, KG Ruggeberg… - PLoS …, 2022 - journals.plos.org
Vibrio cholerae is the etiologic agent of the severe human diarrheal disease cholera. To
colonize mammalian hosts, this pathogen must defend against host-derived toxic …

In Vivo Nitrosative Stress‐Induced Expression of a Photolyase Promotes Vibrio cholerae Environmental Blue Light Resistance

A Banerjee, H Byun, AJ Hrycko, Q Pu… - Molecular …, 2025 - Wiley Online Library
Bacterial pathogens possess a remarkable capacity to sense and adapt to ever‐changing
environments. For example, Vibrio cholerae, the causative agent of the severe diarrheal …

The regulatory network comprising ArcAB‐RpoS‐RssB influences motility in Vibrio cholerae

M Wölflingseder, VH Fengler… - Molecular …, 2024 - Wiley Online Library
The diarrheal disease cholera is caused by the versatile and responsive bacterium Vibrio
cholerae, which is capable of adapting to environmental changes. Among others, the …

Central metabolism is a key player in E. coli biofilm stimulation by sub-MIC antibiotics

LN Yaeger, S French, ED Brown, JP Côté… - Plos Genetics, 2023 - journals.plos.org
Exposure of Escherichia coli to sub-inhibitory antibiotics stimulates biofilm formation through
poorly characterized mechanisms. Using a high-throughput Congo Red binding assay to …

Trade-offs between receptor modification and fitness drive host-bacteriophage co-evolution leading to phage extinction or co-existence

L Chen, X Zhao, S Wongso, Z Lin, S Wang - The ISME Journal, 2024 - academic.oup.com
Parasite–host co-evolution results in population extinction or co-existence, yet the factors
driving these distinct outcomes remain elusive. In this study, Salmonella strains were …

Conserved metabolic regulator ArcA responds to oxygen availability, iron limitation, and cell envelope perturbations during bacteremia

AN Brown, MT Anderson, SN Smith, MA Bachman… - Mbio, 2023 - Am Soc Microbiol
Gram-negative facultative anaerobes often cause bacteremia, a systemic infection
associated with severe clinical outcomes. ArcAB, a two-component regulatory system that …