Chloroquine and sulfadoxine–pyrimethamine resistance in Sub-Saharan Africa—A review
Malaria is a great concern for global health and accounts for a large amount of morbidity and
mortality, particularly in Africa, with sub-Saharan Africa carrying the greatest burden of the …
mortality, particularly in Africa, with sub-Saharan Africa carrying the greatest burden of the …
The host targeting effect of chloroquine in malaria
C Coban - Current opinion in immunology, 2020 - Elsevier
Highlights•Chloroquine/hydroxychloroquine is an old anti-malarial drug belongs to 4-
aminoquinolines.•Chloroquine has additional anti-virus, anti-bacteria, anti-protozoan, anti …
aminoquinolines.•Chloroquine has additional anti-virus, anti-bacteria, anti-protozoan, anti …
Antimalarial quinoline drugs inhibit β-hematin and increase free hemin catalyzing peroxidative reactions and inhibition of cysteine proteases
Malaria caused by Plasmodium affects millions people worldwide. Plasmodium consumes
hemoglobin during its intraerythrocytic stage leaving toxic heme. Parasite detoxifies free …
hemoglobin during its intraerythrocytic stage leaving toxic heme. Parasite detoxifies free …
Repurposing chloroquine against multiple diseases with special attention to SARS-CoV-2 and associated toxicity
Chloroquine and its derivatives have been used since ages to treat malaria and have also
been approved by the FDA to treat autoimmune diseases. The drug employs pH-dependent …
been approved by the FDA to treat autoimmune diseases. The drug employs pH-dependent …
[HTML][HTML] Exploring the Antimalarial Efficacy of Globimetula oreophila Leaf Fractions in Plasmodium berghei-infected Mice: In Vivo Approach
The development of parasite resistance to first-line antimalarial medicines, especially the
Artemisinin-based combination therapies (ACTs), has made the research and development …
Artemisinin-based combination therapies (ACTs), has made the research and development …
PfMDR1 Transport Rates Assessed in Intact Isolated Plasmodium falciparum Digestive Vacuoles Reflect Functional Drug Resistance Relationship with pfmdr1 …
N Simon, C Voigtländer, B Kappes, P Rohrbach… - Pharmaceuticals, 2022 - mdpi.com
Drug resistance often emerges from mutations in solute transporters. Single amino acid
exchanges may alter functionality of transporters with 'de novo'ability to transport drugs away …
exchanges may alter functionality of transporters with 'de novo'ability to transport drugs away …
Antimalarial drugs
Malaria is a mosquito-borne infectious disease that remains one of the world's most frequent
causes of morbidity and mortality. According to the World Malaria Report 2021, published by …
causes of morbidity and mortality. According to the World Malaria Report 2021, published by …
Uptake of a fluorescently tagged chloroquine analogue is reduced in CQ-resistant compared to CQ-sensitive Plasmodium falciparum parasites
SJ Reiling, P Rohrbach - Malaria Journal, 2019 - Springer
Background Chloroquine (CQ) was the drug of choice for decades in the treatment of
falciparum malaria until resistance emerged. CQ is suggested to accumulate in the …
falciparum malaria until resistance emerged. CQ is suggested to accumulate in the …
Identification of an inhibitory pocket in falcilysin provides a new avenue for malaria drug development
Identification of new druggable protein targets remains the key challenge in the current
antimalarial development efforts. Here we used mass-spectrometry-based cellular thermal …
antimalarial development efforts. Here we used mass-spectrometry-based cellular thermal …
Recombinant C-Terminal Domains from Scorpine-like Peptides Inhibit the Plasmodium berghei Ookinete Development In Vitro
L Vargas-Jaimes, MC Rodriguez… - International Journal of …, 2021 - Springer
Malaria is a parasitic disease, caused by protozoa of the genus Plasmodium, and is
transmitted to humans through the bites of infected Anopheles mosquitoes. More than 200 …
transmitted to humans through the bites of infected Anopheles mosquitoes. More than 200 …