Wnt/β‐catenin signalling is known to play many roles in metazoan development and tissue
homeostasis. Misregulation of the pathway has also been linked to many human diseases …

Organoids, or miniaturized organs formed in vitro, hold potential to revolutionize how
researchers approach and answer fundamental biological and pathological questions. In the …

The discovery of the first heart field (FHF) and the second heart field (SHF) led us to
understand how cardiac lineages and structures arise during development. However, it …

OBJECTIVE: Alcohol (ethanol) consumption during pregnancy is linked to congenital heart
defects that are associated with fetal alcohol syndrome. Recent reports have associated …

Wnt signaling mediated by β-catenin has been implicated in early endocardial cushion
development, but its roles in later stages of heart valve maturation and homeostasis have …

Defects in the assembly or function of primary cilia, which are sensory organelles, are tightly
coupled to developmental defects and diseases in mammals. Here, we investigated the …

A complex regulatory network of morphogens and transcription factors is essential for
normal cardiac development. Nkx2-5 is among the earliest known markers of cardiac …

The fruit fly Drosophila melanogaster has emerged as a useful model for cardiac diseases,
both developmental abnormalities and adult functional impairment. Using the tools of both …

Extrapolating from animal studies to human pregnancy, our studies showed that folate (FA)
deficiency as well as one‐time exposure to environmental factors in the first two to three …

Objective. To investigate the expression of HOX transcript antisense RNA (HOTAIR) in
cardiac tissues and plasma of patients with congenital heart diseases (CHDs). Methods …