Effective drug therapy to optimally influence disease requires an understanding of a drug's
pharmacokinetic, pharmacodynamic, and pharmacogenomic interrelationships. In …

UDP-glycosyltransferases (UGTs) catalyze the covalent addition of sugars to a broad range
of lipophilic molecules. This biotransformation plays a critical role in elimination of a broad …

Human UDP-glucuronosyltransferase (UGT) exists as a superfamily of 22 proteins, which
are divided into 5 families and 6 subfamilies on the basis of sequence identity. Members of …

UDP-glucuronosyltransferase (UGT) and esterases are recognized as the most important
non-P450 enzymes because of their high contribution to drug metabolism. UGTs catalyze …

The antiretroviral protease inhibitor atazanavir inhibits hepatic uridine diphosphate
glucuronosyltransferase (UGT) 1A1, thereby preventing the glucuronidation and elimination …

Glucuronidation by uridine diphospho‐glucuronosyltransferase enzymes (UGTs) is a major
phase II biotransformation pathway and, complementary to phase I metabolism and …

Aim: Cigarette smoking influences DNA methylation genome wide, in newborns from
pregnancy exposure and in adults from personal smoking. Whether a unique methylation …

Glucuronidation is an important metabolic pathway for many small endogenous and
exogenous lipophilic compounds, including bilirubin, steroid hormones, bile acids …

Abstract Bisphenol S (BPS; bis [4-hydroxyphenyl] sulfone) is commonly used as a
replacement for bisphenol A in numerous consumer products. The main goal of this study …

Renal metabolism by UDP-glucuronosyltransferase (UGT) enzymes is central to the
clearance of many drugs. However, significant discrepancies about the relative abundance …