Histone deacetylases (HDACs) play an important role in regulating target gene expression.
They have been highlighted as a novel category of anticancer targets, and their inhibition …

High-grade serous ovarian carcinoma (HGSOC) is the most aggressive type of ovarian
cancer, often diagnosed at advanced stages. Molecularly, HGSOC shows high degree of …

Protein serine/threonine phosphatases (PPPs) are ancient enzymes, with distinct types
conserved across eukaryotic evolution. PPPs are segregated into types primarily on the …

Transcription elongation regulates the expression of many genes, including oncogenes.
Histone deacetylase (HDAC) inhibitors (HDACIs) block elongation, suggesting that HDACs …

The bromodomain and extraterminal (BET) subfamily of bromodomain-containing proteins
has emerged in the last few years as an exciting, novel target group. BRD4, the best studied …

Bromodomain-containing protein 4 (BRD4) and histone deacetylases (HDAC) are both
attractive epigenetic targets in cancer and other chronic diseases. Based on the integrated …

Abstract Romidepsin (FK228), a histone deacetylase inhibitor (HDACi), has anti-tumor
effects against several types of solid tumors. Studies have suggested that HDACi could …

Metastasis is the leading cause of cancer-related death. The interactions between
circulating tumor cells and endothelial adhesion molecules in distant organs is a key step …

Objective Homologous recombination (HR)-proficient ovarian tumors have poorer clinical
outcomes and show resistance to poly ADP ribose polymerase inhibitors (PARPi). A subset …

Long non-coding RNAs (lncRNAs) play an important role in gene regulation and are
involving in diverse cellular processes. However, their roles in reprogramming of gene …